Iron-catalyzed cross-coupling between 1-Bromoalkynes and Grignard-derived organocuprate reagents

Daniele Castagnolo; Maurizio Botta

doi:10.1002/ejoc.201000393

Iron-catalyzed cross-coupling between 1-Bromoalkynes and Grignard-derived organocuprate reagents

Daniele Castagnolo, Maurizio Botta

Northumbria University

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes

Original language	English
Pages (from-to)	3224-3228
Journal	European Journal of Organic Chemistry
Volume	2010
Issue number	17
DOIs	https://doi.org/10.1002/ejoc.201000393
Publication status	Published - 2010

Keywords

alkynes
Iron
Grignard reagents
homogeneous catalysis

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10.1002/ejoc.201000393

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title = "Iron-catalyzed cross-coupling between 1-Bromoalkynes and Grignard-derived organocuprate reagents",

abstract = "An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes",

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author = "Daniele Castagnolo and Maurizio Botta",

year = "2010",

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language = "English",

volume = "2010",

pages = "3224--3228",

journal = "European Journal of Organic Chemistry",

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TY - JOUR

T1 - Iron-catalyzed cross-coupling between 1-Bromoalkynes and Grignard-derived organocuprate reagents

AU - Castagnolo, Daniele

AU - Botta, Maurizio

PY - 2010

Y1 - 2010

N2 - An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes

AB - An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes

KW - alkynes

KW - Iron

KW - Grignard reagents

KW - homogeneous catalysis

UR - https://www.scopus.com/pages/publications/77952998349

U2 - 10.1002/ejoc.201000393

DO - 10.1002/ejoc.201000393

M3 - Article

SN - 0075-4617

VL - 2010

SP - 3224

EP - 3228

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 17

ER -

Iron-catalyzed cross-coupling between 1-Bromoalkynes and Grignard-derived organocuprate reagents

Abstract

Keywords

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