Is Cortical Activation during Walking Different between Parkinson's Disease Motor Subtypes?

Diego Orcioli-Silva, Rodrigo Vitório, Victor Spiandor Beretta, Núbia Ribeiro Da Conceição, Priscila Nóbrega-Sousa, Anderson Souza Oliveira, Lilian Teresa Bucken Gobbi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Parkinson's disease (PD) is often classified into tremor dominant (TD) and postural instability gait disorder (PIGD) subtypes. Degeneration of subcortical/cortical pathways is different betweenPD subtypes, which leads to differences in motor behavior. However, the influence of PD subtype on cortical activity during walking remains poorly understood. Therefore, we aimed to investigate the influence of PD motor subtypes on cortical activity during unobstructed walking and obstacle avoidance. Seventeen PIGD and 19 TD patients performed unobstructed walking and obstacle avoidance conditions. Brain activity was measured using a mobile functional near-infrared spectroscopy-electroencephalography (EEG) systems, and gait parameters were analyzed using an electronic carpet. Concentrations of oxygenated hemoglobin (HbO2) of the prefrontal cortex (PFC) and EEG absolute power from alpha, beta, and gamma bands in FCz, Cz, CPz, and Oz channels were calculated. These EEG channels correspond to supplementary motor area, primary motor cortex, posterior parietal cortex, and visual cortex, respectively. Postural instability gait disorder patients presented higher PFC activity than TD patients, regardless of the walking condition. Tremor dominant patients presented reduced beta power in the Cz channel during obstacle avoidance compared to unobstructed walking. Both TDand PIGD patients decreased alpha and beta power in the FCz and CPz channels. In conclusion, PIGD patients need to recruit additional cognitive resources from the PFC for walking. Both TD and PIGD patients presented changes in the activation of brain areas related to motor/sensorimotor areas in order to maintain balance control during obstacle avoidance, being that TD patients presented further changes in the motor area (Cz channel) to avoid obstacles.

Original languageEnglish
Pages (from-to)561-567
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume76
Issue number4
Early online date16 Jul 2020
DOIs
Publication statusPublished - 31 Mar 2021
Externally publishedYes

Fingerprint

Dive into the research topics of 'Is Cortical Activation during Walking Different between Parkinson's Disease Motor Subtypes?'. Together they form a unique fingerprint.

Cite this