Joint Models of Longitudinal and Time-to-Event Data with More Than One Event Time Outcome: A Review

Graeme L. Hickey, Pete Philipson, Andrea Jorgensen, Ruwanthi Kolamunnage-dona

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)
23 Downloads (Pure)

Abstract

Methodological development and clinical application of joint models of longitudinal and time-to-event outcomes have grown substantially over the past two decades. However, much of this research has concentrated on a single longitudinal outcome and a single event time outcome. In clinical and public health research, patients who are followed up over time may often experience multiple, recurrent, or a succession of clinical events. Models that utilise such multivariate event time outcomes are quite valuable in clinical decision-making. We comprehensively review the literature for implementation of joint models involving more than a single event time per subject. We consider the distributional and modelling assumptions, including the association structure, estimation approaches, software implementations, and clinical applications. Research into this area is proving highly promising, but to-date remains in its infancy.
Original languageEnglish
JournalInternational Journal of Biostatistics
Volume14
Issue number1
DOIs
Publication statusPublished - 31 Jan 2018

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