Ketogenic diet and olanzapine treatment alone and in combination reduce a pharmacologically-induced prepulse inhibition deficit in female mice

Ann Katrin Kraeuter, Nadia Archambault, Maarten van den Buuse, Zoltán Sarnyai

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We used the acute NMDA receptor hypoactivity model of schizophrenia in mice to compare the efficacy of a long-term ketogenic diet and a commonly used antipsychotic, olanzapine, and to explore the interaction between these treatments. We found that a ketogenic diet in female mice was as effective as olanzapine to diminish MK-801-induced disruption of prepulse inhibition (PPI). Furthermore, combination of the diet with olanzapine treatment resulted in a similar effect compared to either treatment alone. These results suggest that ketogenic diet can be used effectively together with antipsychotics drugs over an extended period.
Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalSchizophrenia Research
Volume212
Early online date9 Aug 2019
DOIs
Publication statusPublished - 1 Oct 2019
Externally publishedYes

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