Abstract
We used the acute NMDA receptor hypoactivity model of schizophrenia in mice to compare the efficacy of a long-term ketogenic diet and a commonly used antipsychotic, olanzapine, and to explore the interaction between these treatments. We found that a ketogenic diet in female mice was as effective as olanzapine to diminish MK-801-induced disruption of prepulse inhibition (PPI). Furthermore, combination of the diet with olanzapine treatment resulted in a similar effect compared to either treatment alone. These results suggest that ketogenic diet can be used effectively together with antipsychotics drugs over an extended period.
Original language | English |
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Pages (from-to) | 221-224 |
Number of pages | 4 |
Journal | Schizophrenia Research |
Volume | 212 |
Early online date | 9 Aug 2019 |
DOIs | |
Publication status | Published - 1 Oct 2019 |
Externally published | Yes |
Keywords
- Ketogenic diet
- MK-801
- NMDA receptors
- Olanzapine
- Prepulse inhibition
- Schizophrenia