Lactoferrin: Antimicrobial activity and therapeutic potential

Nicholas Embleton; Janet Berrington; William McGuire; Christopher Stewart; Stephen Cummings

doi:10.1016/j.siny.2013.02.001

Lactoferrin: Antimicrobial activity and therapeutic potential

Nicholas Embleton, Janet Berrington, William McGuire, Christopher Stewart, Stephen Cummings

Northumbria University

Research output: Contribution to journal › Article › peer-review

102 Citations (Scopus)

Abstract

Lactoferrin is a highly conserved protein from an evolutionary perspective, with a wide range of roles related to protection from infection and promotion of nutritional status. Infection, malnutrition and intestinal pathologies are key inter-related problems, represent important threats to survival and are associated with adverse long-term health outcomes after preterm birth. Lactoferrin is available as a commercial extract from bovine milk and offers potential as a therapeutic intervention for preterm infants modulating infections and intestinal pathologies. In this review we explore the structure, direct antimicrobial effects, modification of host immune function and gastrointestinal effects of lactoferrin. Current trial data are reviewed, and research priorities and challenges identified and discussed.

Original language	English
Pages (from-to)	143-149
Journal	Seminars in Fetal and Neonatal Medicine
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/j.siny.2013.02.001
Publication status	Published - 2013

Keywords

lactoferrin
late-onset infection
microbiome
necrotising enterocolitis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.siny.2013.02.001

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abstract = "Lactoferrin is a highly conserved protein from an evolutionary perspective, with a wide range of roles related to protection from infection and promotion of nutritional status. Infection, malnutrition and intestinal pathologies are key inter-related problems, represent important threats to survival and are associated with adverse long-term health outcomes after preterm birth. Lactoferrin is available as a commercial extract from bovine milk and offers potential as a therapeutic intervention for preterm infants modulating infections and intestinal pathologies. In this review we explore the structure, direct antimicrobial effects, modification of host immune function and gastrointestinal effects of lactoferrin. Current trial data are reviewed, and research priorities and challenges identified and discussed.",

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AU - Embleton, Nicholas

AU - Berrington, Janet

AU - McGuire, William

AU - Stewart, Christopher

AU - Cummings, Stephen

PY - 2013

Y1 - 2013

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AB - Lactoferrin is a highly conserved protein from an evolutionary perspective, with a wide range of roles related to protection from infection and promotion of nutritional status. Infection, malnutrition and intestinal pathologies are key inter-related problems, represent important threats to survival and are associated with adverse long-term health outcomes after preterm birth. Lactoferrin is available as a commercial extract from bovine milk and offers potential as a therapeutic intervention for preterm infants modulating infections and intestinal pathologies. In this review we explore the structure, direct antimicrobial effects, modification of host immune function and gastrointestinal effects of lactoferrin. Current trial data are reviewed, and research priorities and challenges identified and discussed.

KW - lactoferrin

KW - late-onset infection

KW - microbiome

KW - necrotising enterocolitis

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M3 - Article

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JO - Seminars in Fetal and Neonatal Medicine

JF - Seminars in Fetal and Neonatal Medicine

IS - 3

ER -

Lactoferrin: Antimicrobial activity and therapeutic potential

Abstract

Keywords

UN SDGs

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