Lactoferrin: Antimicrobial activity and therapeutic potential

Nicholas Embleton, Janet Berrington, William McGuire, Christopher Stewart, Stephen Cummings

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)

Abstract

Lactoferrin is a highly conserved protein from an evolutionary perspective, with a wide range of roles related to protection from infection and promotion of nutritional status. Infection, malnutrition and intestinal pathologies are key inter-related problems, represent important threats to survival and are associated with adverse long-term health outcomes after preterm birth. Lactoferrin is available as a commercial extract from bovine milk and offers potential as a therapeutic intervention for preterm infants modulating infections and intestinal pathologies. In this review we explore the structure, direct antimicrobial effects, modification of host immune function and gastrointestinal effects of lactoferrin. Current trial data are reviewed, and research priorities and challenges identified and discussed.
Original languageEnglish
Pages (from-to)143-149
JournalSeminars in Fetal and Neonatal Medicine
Volume18
Issue number3
DOIs
Publication statusPublished - 2013

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