Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype

Bryony Curry; Aimee L. Drane; Rebeca Atencia; Yedra Feltrer; Thalita Calvi; Ellie L. Milnes; Sophie Moittie; Annika Weigold; Tobias Knauf-Witzens; Arga Sawung Kusuma; Glyn Howatson; Christopher Palmer; Mike R. Stembridge; John E. Gorzynski; Neil D. Eves; Tony Dawkins; Rob E. Shave

doi:10.1038/s42003-024-06280-9

Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype

Bryony Curry, Aimee L. Drane^*, Rebeca Atencia, Yedra Feltrer, Thalita Calvi, Ellie L. Milnes, Sophie Moittie, Annika Weigold, Tobias Knauf-Witzens, Arga Sawung Kusuma, Glyn Howatson, Christopher Palmer, Mike R. Stembridge, John E. Gorzynski, Neil D. Eves, Tony Dawkins, Rob E. Shave^*

^*Corresponding author for this work

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Abstract

Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon, using 2D echocardiography, to gain insight into the evolution of the human heart. We present compelling evidence that the human LV has diverged away from a more trabeculated phenotype present in all other great apes, towards a ventricular wall with proportionally greater compact myocardium, which was corroborated by post-mortem chimpanzee (Pan troglodytes) hearts. Speckle-tracking echocardiographic analyses identified a negative curvilinear relationship between the degree of trabeculation and LV systolic twist, revealing lower rotational mechanics in the trabeculated non-human great ape LV. This divergent evolution of the human heart may have facilitated the augmentation of cardiac output to support the metabolic and thermoregulatory demands of the human ecological niche.

Original language	English
Article number	682
Pages (from-to)	1-9
Number of pages	9
Journal	Communications Biology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s42003-024-06280-9
Publication status	Published - 14 Jun 2024

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Curry, B., Drane, A. L., Atencia, R., Feltrer, Y., Calvi, T., Milnes, E. L., Moittie, S., Weigold, A., Knauf-Witzens, T., Sawung Kusuma, A., Howatson, G., Palmer, C., Stembridge, M. R., Gorzynski, J. E., Eves, N. D., Dawkins, T., & Shave, R. E. (2024). Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype. Communications Biology, 7(1), 1-9. Article 682. https://doi.org/10.1038/s42003-024-06280-9

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title = "Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype",

abstract = "Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon, using 2D echocardiography, to gain insight into the evolution of the human heart. We present compelling evidence that the human LV has diverged away from a more trabeculated phenotype present in all other great apes, towards a ventricular wall with proportionally greater compact myocardium, which was corroborated by post-mortem chimpanzee (Pan troglodytes) hearts. Speckle-tracking echocardiographic analyses identified a negative curvilinear relationship between the degree of trabeculation and LV systolic twist, revealing lower rotational mechanics in the trabeculated non-human great ape LV. This divergent evolution of the human heart may have facilitated the augmentation of cardiac output to support the metabolic and thermoregulatory demands of the human ecological niche.",

author = "Bryony Curry and Drane, {Aimee L.} and Rebeca Atencia and Yedra Feltrer and Thalita Calvi and Milnes, {Ellie L.} and Sophie Moittie and Annika Weigold and Tobias Knauf-Witzens and {Sawung Kusuma}, Arga and Glyn Howatson and Christopher Palmer and Stembridge, {Mike R.} and Gorzynski, {John E.} and Eves, {Neil D.} and Tony Dawkins and Shave, {Rob E.}",

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doi = "10.1038/s42003-024-06280-9",

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Curry, B, Drane, AL, Atencia, R, Feltrer, Y, Calvi, T, Milnes, EL, Moittie, S, Weigold, A, Knauf-Witzens, T, Sawung Kusuma, A, Howatson, G, Palmer, C, Stembridge, MR, Gorzynski, JE, Eves, ND, Dawkins, T & Shave, RE 2024, 'Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype', Communications Biology, vol. 7, no. 1, 682, pp. 1-9. https://doi.org/10.1038/s42003-024-06280-9

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T1 - Left ventricular trabeculation in Hominidae

T2 - divergence of the human cardiac phenotype

AU - Curry, Bryony

AU - Drane, Aimee L.

AU - Atencia, Rebeca

AU - Feltrer, Yedra

AU - Calvi, Thalita

AU - Milnes, Ellie L.

AU - Moittie, Sophie

AU - Weigold, Annika

AU - Knauf-Witzens, Tobias

AU - Sawung Kusuma, Arga

AU - Howatson, Glyn

AU - Palmer, Christopher

AU - Stembridge, Mike R.

AU - Gorzynski, John E.

AU - Eves, Neil D.

AU - Dawkins, Tony

AU - Shave, Rob E.

PY - 2024/6/14

Y1 - 2024/6/14

N2 - Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon, using 2D echocardiography, to gain insight into the evolution of the human heart. We present compelling evidence that the human LV has diverged away from a more trabeculated phenotype present in all other great apes, towards a ventricular wall with proportionally greater compact myocardium, which was corroborated by post-mortem chimpanzee (Pan troglodytes) hearts. Speckle-tracking echocardiographic analyses identified a negative curvilinear relationship between the degree of trabeculation and LV systolic twist, revealing lower rotational mechanics in the trabeculated non-human great ape LV. This divergent evolution of the human heart may have facilitated the augmentation of cardiac output to support the metabolic and thermoregulatory demands of the human ecological niche.

AB - Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon, using 2D echocardiography, to gain insight into the evolution of the human heart. We present compelling evidence that the human LV has diverged away from a more trabeculated phenotype present in all other great apes, towards a ventricular wall with proportionally greater compact myocardium, which was corroborated by post-mortem chimpanzee (Pan troglodytes) hearts. Speckle-tracking echocardiographic analyses identified a negative curvilinear relationship between the degree of trabeculation and LV systolic twist, revealing lower rotational mechanics in the trabeculated non-human great ape LV. This divergent evolution of the human heart may have facilitated the augmentation of cardiac output to support the metabolic and thermoregulatory demands of the human ecological niche.

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JF - Communications Biology

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ER -

Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype

Abstract

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