Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype

Bryony Curry, Aimee L. Drane*, Rebeca Atencia, Yedra Feltrer, Thalita Calvi, Ellie L. Milnes, Sophie Moittie, Annika Weigold, Tobias Knauf-Witzens, Arga Sawung Kusuma, Glyn Howatson, Christopher Palmer, Mike R. Stembridge, John E. Gorzynski, Neil D. Eves, Tony Dawkins, Rob E. Shave*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon, using 2D echocardiography, to gain insight into the evolution of the human heart. We present compelling evidence that the human LV has diverged away from a more trabeculated phenotype present in all other great apes, towards a ventricular wall with proportionally greater compact myocardium, which was corroborated by post-mortem chimpanzee (Pan troglodytes) hearts. Speckle-tracking echocardiographic analyses identified a negative curvilinear relationship between the degree of trabeculation and LV systolic twist, revealing lower rotation mechanics in the trabeculated non-human great ape LV. This divergent evolution of the human heart may have facilitated the augmentation of cardiac output to support the metabolic and thermoregulatory demands of the human ecological niche.
Original languageEnglish
JournalCommunications Biology
Publication statusAccepted/In press - 5 Apr 2024

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