Lipoprotein biogenesis in gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em

Matthew Hutchings, Tracy Palmer, Dean Harrington, Iain Sutcliffe

Research output: Contribution to journalArticlepeer-review

147 Citations (Scopus)

Abstract

Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new anti-microbials.
Original languageEnglish
Pages (from-to)13-21
JournalTrends in Microbiology
Volume17
Issue number1
DOIs
Publication statusPublished - 2009

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