TY - JOUR
T1 - Lipoprotein biogenesis in gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em
AU - Hutchings, Matthew
AU - Palmer, Tracy
AU - Harrington, Dean
AU - Sutcliffe, Iain
PY - 2009
Y1 - 2009
N2 - Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new anti-microbials.
AB - Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new anti-microbials.
U2 - 10.1016/j.tim.2008.10.001
DO - 10.1016/j.tim.2008.10.001
M3 - Article
SN - 0966-842X
VL - 17
SP - 13
EP - 21
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 1
ER -