Liposome-based carrier systems and devices used for pulmonary drug delivery

Iftikhar Khan*, Abdelbary Elhissi, Mahmood Shah, Mohamed Albed Alhnan, Waqar Ahmed

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

20 Citations (Scopus)

Abstract

Liposomes are spherical lipid carrier vesicles that vary in size (typically in the range of 20. nm to 20. μm), and are composed of single or multi-concentric bilayers, and have the ability to entrap both hydrophilic therapeutic agents within their central aqueous core or lipophilic drugs within their bilayer compartment. These carriers can transport drugs to particular sites of action within the pulmonary system by employing specially designed delivery devices. These devices work through specific mechanisms and their performance depends upon the formulation. Dry powder inhalers deliver dry powdered formulations. By contrast, pressurized metered dose inhalers deliver liquid formulations when an appropriate liquefied propellant is included. However, nebulizers are capable of delivering aqueous suspensions or solutions with no need for inclusion of a propellant. Liposomes were first reported in 1965 and since then significant developments in liposome research have emerged. Liposomes are now well established as carrier systems that accommodate therapeutic agents and deliver them to various sites in the body. Liposomes can sustain the release of the entrapped therapeutic materials, hence enhancing the therapeutic outcome. Liposome carrier systems have been studied extensively for prophylaxis against and the treatment of pulmonary diseases.

Original languageEnglish
Title of host publicationBiomaterials and medical tribology
Subtitle of host publicationresearch and development
EditorsJ. Paulo Davim
Place of PublicationOxford
PublisherWoodhead Publishing
Chapter9.1 -
Pages395-443
Number of pages49
Volume65
ISBN (Electronic)9780857092205
ISBN (Print)9780857090171
DOIs
Publication statusPublished - Jul 2013
Externally publishedYes

Publication series

NameWoodhead Publishing Series in Biomaterials
PublisherWoodhead Publishing
Volume65

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