The present study used a target–target procedure to examine the extent to which perceptual and response factors contribute to inhibition of return (IOR) in a visual discrimination task. When the target was perceptually identical to the previous target and the required response was the same, facilitation was observed for both standard and long-term target–target stimulus onset asynchronies (SOAs). When the color of the previous target differed from that of the current target but the response remained the same, facilitation was reduced in both the standard SOA and long-term SOA conditions. Finally, IOR was observed for both standard and long-term SOAs only in the condition in which there was a change in response. This pattern of inhibition and facilitation provides new evidence that the responses previously associated with a location play an important role in the ability to respond to a stimulus. We interpret this finding as consistent with a framework in which the involuntary retrieval of bound stimulus–response episodes contributes to response compatibility effects in visual stimulus discrimination.