Low Doses of Δ-9 Tetrahydrocannabinol (THC) Have Divergent Effects on Short-Term Spatial Memory in Young, Healthy Adults

Petra Mäkelä, Judi Wakeley, Harm Gijsman, Phillip J. Robson, Zubin Bhagwagar, Robert D. Rogers

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Evidence suggests that manipulating spatial information within working memory depends upon a circuitry organized around the prefrontal cortex (PFC) and the activity of the catecholamine systems. Other evidence attests to the effects of Δ-9 tetrahydrocannabinol (THC) on short-term spatial memory function, most probably involving CB1 receptor activity within hippocampal circuitries. At the current time, there have been no systematic studies of the effects of THC on spatial working memory in human subjects using tasks known to depend upon frontotemporal neural circuitries. We examined the effects of a single sublingual 5 mg dose of THC on a test of spatial working memory (requiring active manipulation of remembered spatial information for the management of future behavior) and a test of spatial span (requiring only the reproduction of sequences of previously presented spatial cues). In all, 19 healthy adults were administered 5 mg THC and placebo in a double-blind, placebo-controlled, within-subject, crossover design. Male participants performed more accurately than female participants. THC significantly enhanced spatial working memory performance of female participants. By contrast, male and female participants produced more intrusion errors during performance of the Spatial Span task. These results suggest that THC has relatively complex effects on spatial memory in human subjects, perhaps reflecting altered CB1 receptor activity within frontotemporal circuits or altered activity of mesocortical dopaminergic pathways in PFC areas associated with spatial memory.
Original languageEnglish
Pages (from-to)462-470
Number of pages9
JournalNeuropsychopharmacology
Volume31
Issue number2
Early online date21 Sept 2005
DOIs
Publication statusPublished - 1 Feb 2006
Externally publishedYes

Keywords

  • Spatial working memory
  • Spatial span
  • Cannabis
  • D-9 tetrahydrocannabinol
  • Working memory
  • Prefrontal cortex
  • CB1 receptors

Cite this