Lycopene and Tomato and risk of cardiovascular diseases: A systematic review and meta-analysis of epidemiological evidence

Ho M. Cheng, Georgios Koutsidis, John Lodge, Ashor Ammar, Mario Siervo, Jose Lara Gallegos

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)
36 Downloads (Pure)

Abstract

Background and aims: Worldwide, cardiovascular diseases (CVDs) remains as the main cause of mortality. Observational studies supports an association between intake of tomato products or lycopene with a reduced CVDs risk. Our aim was to undertake a systematic review and meta-analysis of the evidence on the topic. Methods: Medline, Web of Science, and Scopus were searched from inception until July 2017. We included longitudinal and cross-sectional studies reporting associations between lycopene and tomato consumption and cardiovascular morbidity and mortality among adult subjects. Random-effects models were used to determine the pooled effect sizes. Results: Twenty-eight publications met our inclusion criteria and 25 studies provided quantitative data for meta-analysis. Results showed that individuals in the highest consumption category of, or with the highest serum concentration of, lycopene had significantly lower risk of stroke (hazard ratio (HR) 0.74, 0.62–0.89, p = 0.02; I2 = 32) and CVDs (HR 0.86, 0.77–0.95, p = 0.003; I2 = 0). In addition, individuals categorised in the highest serum concentration of lycopene also had significantly lower risk of mortality (HR 0.63, 0.49–0.81, p
Original languageEnglish
Pages (from-to)141-158
JournalCritical Reviews in Food Science and Nutrition
Volume59
Issue number1
Early online date11 Aug 2017
DOIs
Publication statusPublished - 2 Jan 2019

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