Abstract
Background and aims: Worldwide, cardiovascular diseases (CVDs) remains as the main cause of mortality. Observational studies supports an association between intake of tomato products or lycopene with a reduced CVDs risk. Our aim was to undertake a systematic review and meta-analysis of the evidence on the topic.
Methods: Medline, Web of Science, and Scopus were searched from inception until July 2017. We included longitudinal and cross-sectional studies reporting associations between lycopene and tomato consumption and cardiovascular morbidity and mortality among adult subjects. Random-effects models were used to determine the pooled effect sizes.
Results: Twenty-eight publications met our inclusion criteria and 25 studies provided quantitative data for meta-analysis. Results showed that individuals in the highest consumption category of, or with the highest serum concentration of, lycopene had significantly lower risk of stroke (hazard ratio (HR) 0.74, 0.62–0.89, p = 0.02; I2 = 32) and CVDs (HR 0.86, 0.77–0.95, p = 0.003; I2 = 0). In addition, individuals categorised in the highest serum concentration of lycopene also had significantly lower risk of mortality (HR 0.63, 0.49–0.81, p
Original language | English |
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Pages (from-to) | 141-158 |
Number of pages | 18 |
Journal | Critical Reviews in Food Science and Nutrition |
Volume | 59 |
Issue number | 1 |
Early online date | 11 Aug 2017 |
DOIs | |
Publication status | Published - 2 Jan 2019 |
Keywords
- tomato
- lycopene
- cardiovascular disease
- mortality
- systematic review
- meta-analysis