Macrocyclization of Di-Boc-guanidino-alkylamines Related to Guazatine Components: Discovery and synthesis of innovative macrocyclic amidinoureas

Daniele Castagnolo, Francesco Raffi, Gianluca Giorgi, Maurizio Botta

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

The synthesis of new and innovative macrocyclic amidinoureas from linear di-Boc-guanidino-alkylamines related to guazatine was accomplished. The macrocyclization reaction proceeds under mild conditions affording 11- to 16-membered rings with a new and previously undescribed structure in good yields. Enantiomerically pure macrocyclic amidinoureas were also synthesised. The strict correlation between macrocyclic amidinoureas and the natural productguazatine makes them very actractive also from a biological point of view.
Original languageEnglish
Pages (from-to)334-337
JournalEuropean Journal of Organic Chemistry
Volume2009
Issue number3
DOIs
Publication statusPublished - 2009

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