Malaria parasites co-opt human factor h to prevent complement-mediated lysis in the mosquito midgut

Nina Simon, Edwin Lasonder, Matthias Scheuermayer, Andrea Kuehn, Sabrina Tews, Rainer Fischer, Peter F. Zipfel, Christine Skerka, Gabriele Pradel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)


Human complement is a first line defense against infection in which circulating proteins initiate an enzyme cascade on the microbial surface that leads to phagocytosis and lysis. Various pathogens evade complement recognition by binding to regulator proteins that protect host cells from complement activation. We show that emerging gametes of the malaria parasite Plasmodium falciparum bind the host complement regulator factor H (FH) following transmission to the mosquito to protect from complement-mediated lysis by the blood meal. Human complement is active in the mosquito midgut for approximately 1 hr postfeeding. During this period, the gamete surface protein PfGAP50 binds to FH and uses surface-bound FH to inactivate the complement protein C3b. Loss of FH-mediated protection, either through neutralization of FH or blockade of PfGAP50, significantly impairs gametogenesis and inhibits parasite transmission to the mosquito. Thus, Plasmodium co-opts the protective host protein FH to evade complement-mediated lysis within the mosquito midgut.

Original languageEnglish
Pages (from-to)29-41
Number of pages13
JournalCell Host and Microbe
Issue number1
Early online date16 Jan 2013
Publication statusPublished - 16 Jan 2013
Externally publishedYes


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