This article discusses the management of levodopa for older people who have Parkinson’s disease and live in nursing homes. It provides a detailed description of the diagnostic criteria and motor and non-motor clinical features. Against this clinical picture, the benefits and challenges of levodopa management are considered. A person-centred approach is championed, as it supports collaborative clinical assessment and decision making between nurses and residents. To appreciate why a person-centred approach is important for safe and effective medication practice, the pharmacological basis of levodopa management is explained. An empowerment approach to medication management is advocated that facilitates self-medication by residents. To this end, the importance of continuing professional development for nursing home staff is discussed.