Mathematical modeling of gonadotropin-releasing hormone signaling

Amitesh Pratap, Kathryn Garner, Margaritis Voliotis, Krasimira Tsaneva-Atanasova, Craig A McArdle

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)
10 Downloads (Pure)

Abstract

Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.
Original languageEnglish
Pages (from-to)42-55
Number of pages14
JournalMolecular and Cellular Endocrinology
Volume449
Early online date17 Aug 2016
DOIs
Publication statusPublished - 5 Jul 2017
Externally publishedYes

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