Mathematical modeling of gonadotropin-releasing hormone signaling

Amitesh Pratap; Kathryn Garner; Margaritis Voliotis; Krasimira Tsaneva-Atanasova; Craig A McArdle

doi:10.1016/j.mce.2016.08.022

Mathematical modeling of gonadotropin-releasing hormone signaling

Amitesh Pratap, Kathryn Garner, Margaritis Voliotis, Krasimira Tsaneva-Atanasova, Craig A McArdle

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

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Abstract

Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.

Original language	English
Pages (from-to)	42-55
Number of pages	14
Journal	Molecular and Cellular Endocrinology
Volume	449
Early online date	17 Aug 2016
DOIs	https://doi.org/10.1016/j.mce.2016.08.022
Publication status	Published - 5 Jul 2017
Externally published	Yes

Keywords

GnRH
GPCR
NFAT
ERK
Mathematical modeling
Mutual information

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10.1016/j.mce.2016.08.022Licence: CC BY

1-s2.0-S0303720716303161-mainFinal published version, 1.73 MBLicence: CC BY

Cite this

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title = "Mathematical modeling of gonadotropin-releasing hormone signaling",

abstract = "Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.",

keywords = "GnRH, GPCR, NFAT, ERK, Mathematical modeling, Mutual information",

author = "Amitesh Pratap and Kathryn Garner and Margaritis Voliotis and Krasimira Tsaneva-Atanasova and McArdle, \{Craig A\}",

note = "This work was funded Project Grants from MRC (93447) and the BBSRC (J014699). KTA and MV gratefully acknowledge the financial support of the EPSRC via grant EP/N014391/1 and an MRC Biomedical Informatics Fellowship (MR/K021826/1), respectively.",

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day = "5",

doi = "10.1016/j.mce.2016.08.022",

language = "English",

volume = "449",

pages = "42--55",

journal = "Molecular and Cellular Endocrinology",

issn = "0303-7207",

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TY - JOUR

T1 - Mathematical modeling of gonadotropin-releasing hormone signaling

AU - Pratap, Amitesh

AU - Garner, Kathryn

AU - Voliotis, Margaritis

AU - Tsaneva-Atanasova, Krasimira

AU - McArdle, Craig A

N1 - This work was funded Project Grants from MRC (93447) and the BBSRC (J014699). KTA and MV gratefully acknowledge the financial support of the EPSRC via grant EP/N014391/1 and an MRC Biomedical Informatics Fellowship (MR/K021826/1), respectively.

PY - 2017/7/5

Y1 - 2017/7/5

N2 - Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.

AB - Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.

KW - GnRH

KW - GPCR

KW - NFAT

KW - ERK

KW - Mathematical modeling

KW - Mutual information

UR - https://www.scopus.com/pages/publications/84994885307

U2 - 10.1016/j.mce.2016.08.022

DO - 10.1016/j.mce.2016.08.022

M3 - Review article

SN - 0303-7207

VL - 449

SP - 42

EP - 55

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

ER -

Mathematical modeling of gonadotropin-releasing hormone signaling

Abstract

Keywords

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