Mechanism of thioamide drug action against tuberculosis and leprosy

Feng Wang, Lynn Dover, Gulcin Gulten, Robert Langley, Gurdyal Besra, William Jacobs, James Sacchettini

Research output: Contribution to journalArticlepeer-review

191 Citations (Scopus)

Abstract

Dover developed molecular constructs and the initial in viro data that initiated a structural biology route to the determination of the mode of action of the important anti-TB agent ethionamide used to treat multi-drug resistant infections and its analogue prothionamide used to treat leprosy.
Original languageEnglish
Pages (from-to)73-78
JournalJournal of Experimental Medicine
Volume204
Issue number1
DOIs
Publication statusPublished - Jan 2007

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