Mechanism of thioamide drug action against tuberculosis and leprosy

Feng Wang; Lynn Dover; Gulcin Gulten; Robert Langley; Gurdyal Besra; William Jacobs; James Sacchettini

doi:10.1084/jem.20062100

Mechanism of thioamide drug action against tuberculosis and leprosy

Feng Wang, Lynn Dover, Gulcin Gulten, Robert Langley, Gurdyal Besra, William Jacobs, James Sacchettini

Research output: Contribution to journal › Article › peer-review

266 Citations (Scopus)

Abstract

Dover developed molecular constructs and the initial in viro data that initiated a structural biology route to the determination of the mode of action of the important anti-TB agent ethionamide used to treat multi-drug resistant infections and its analogue prothionamide used to treat leprosy.

Original language	English
Pages (from-to)	73-78
Journal	Journal of Experimental Medicine
Volume	204
Issue number	1
DOIs	https://doi.org/10.1084/jem.20062100
Publication status	Published - Jan 2007

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10.1084/jem.20062100

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title = "Mechanism of thioamide drug action against tuberculosis and leprosy",

abstract = "Dover developed molecular constructs and the initial in viro data that initiated a structural biology route to the determination of the mode of action of the important anti-TB agent ethionamide used to treat multi-drug resistant infections and its analogue prothionamide used to treat leprosy.",

author = "Feng Wang and Lynn Dover and Gulcin Gulten and Robert Langley and Gurdyal Besra and William Jacobs and James Sacchettini",

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AU - Dover, Lynn

AU - Gulten, Gulcin

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AU - Jacobs, William

AU - Sacchettini, James

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U2 - 10.1084/jem.20062100

DO - 10.1084/jem.20062100

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SP - 73

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JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

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Mechanism of thioamide drug action against tuberculosis and leprosy

Abstract

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