Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli

Lingling Zhang; Yunhong Jiang; Yulong Ding; Nikolaos Daskalakis; Lars Jeuken; Malcolm Povey; Alex J. O'Neill; David W. York

doi:10.1007/s11051-009-9711-1

Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli

Lingling Zhang, Yunhong Jiang, Yulong Ding^*, Nikolaos Daskalakis, Lars Jeuken, Malcolm Povey, Alex J. O'Neill, David W. York

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

431 Citations (Scopus)

Abstract

Aqueous suspensions containing 4.45 ×10^-5 - 1.25 ×10^-3 M ZnO particles exhibit a strong antibacterial activity against E. coli under the dark conditions. The dominant mechanisms of such antibacterial behaviour are found to be either or both of chemical interactions between hydrogen peroxide and membrane proteins, and chemical interactionsbetween other unknown chemical species generated due to the presence of ZnO particles with the lipid bilayer. The effect of direct physical interactions between nanoparticles and biological cells are found to play a relatively small role under the con ditions of this study.

Original language	English
Pages (from-to)	1625-1636
Number of pages	12
Journal	Journal of Nanoparticle Research
Volume	12
Issue number	5
Early online date	29 Jul 2009
DOIs	https://doi.org/10.1007/s11051-009-9711-1
Publication status	Published - Jun 2010
Externally published	Yes

Keywords

Antibacterial
E. coli
EHS
Lipid vesicles
Mechanism
Toxicity
ZnO nanoparticles

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10.1007/s11051-009-9711-1

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abstract = "Aqueous suspensions containing 4.45 ×10-5 - 1.25 ×10-3 M ZnO particles exhibit a strong antibacterial activity against E. coli under the dark conditions. The dominant mechanisms of such antibacterial behaviour are found to be either or both of chemical interactions between hydrogen peroxide and membrane proteins, and chemical interactionsbetween other unknown chemical species generated due to the presence of ZnO particles with the lipid bilayer. The effect of direct physical interactions between nanoparticles and biological cells are found to play a relatively small role under the con ditions of this study.",

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author = "Lingling Zhang and Yunhong Jiang and Yulong Ding and Nikolaos Daskalakis and Lars Jeuken and Malcolm Povey and O'Neill, {Alex J.} and York, {David W.}",

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AU - Zhang, Lingling

AU - Jiang, Yunhong

AU - Ding, Yulong

AU - Daskalakis, Nikolaos

AU - Jeuken, Lars

AU - Povey, Malcolm

AU - O'Neill, Alex J.

AU - York, David W.

PY - 2010/6

Y1 - 2010/6

N2 - Aqueous suspensions containing 4.45 ×10-5 - 1.25 ×10-3 M ZnO particles exhibit a strong antibacterial activity against E. coli under the dark conditions. The dominant mechanisms of such antibacterial behaviour are found to be either or both of chemical interactions between hydrogen peroxide and membrane proteins, and chemical interactionsbetween other unknown chemical species generated due to the presence of ZnO particles with the lipid bilayer. The effect of direct physical interactions between nanoparticles and biological cells are found to play a relatively small role under the con ditions of this study.

AB - Aqueous suspensions containing 4.45 ×10-5 - 1.25 ×10-3 M ZnO particles exhibit a strong antibacterial activity against E. coli under the dark conditions. The dominant mechanisms of such antibacterial behaviour are found to be either or both of chemical interactions between hydrogen peroxide and membrane proteins, and chemical interactionsbetween other unknown chemical species generated due to the presence of ZnO particles with the lipid bilayer. The effect of direct physical interactions between nanoparticles and biological cells are found to play a relatively small role under the con ditions of this study.

KW - Antibacterial

KW - E. coli

KW - EHS

KW - Lipid vesicles

KW - Mechanism

KW - Toxicity

KW - ZnO nanoparticles

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M3 - Article

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SN - 1388-0764

VL - 12

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EP - 1636

JO - Journal of Nanoparticle Research

JF - Journal of Nanoparticle Research

IS - 5

ER -

Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli

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Keywords

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