TY - JOUR
T1 - Mediterranean diet and the hallmarks of ageing
AU - Shannon, Oliver M.
AU - Ashor, Ammar W.
AU - Scialo, Filippo
AU - Saretzki, Gabriele
AU - Martin-Ruiz, Carmen
AU - Lara, Jose
AU - Matu, Jamie
AU - Griffiths, Alex
AU - Robinson, Natassia
AU - Lillà, Lionetti
AU - Stevenson, Emma
AU - Stephan, Blossom C.M.
AU - Minihane, Anne Marie
AU - Siervo, Mario
AU - Mathers, John C.
N1 - Funding Information:
Medical Research Council (MRC), Biotechnology and Biological Sciences Research Council (BBSRC) and the National Institute for Health Research (NIHR) (MR/T001852/1).
Alzheimer’s Research UK Prevention and Risk Reduction Fund (ARUK-PRRF2017-006) and the UK Nutrition Research Partnership (UK NRP).
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Ageing is a multifactorial process associated with reduced function and increased risk of morbidity and mortality. Recently, nine cellular and molecular hallmarks of ageing have been identified, which characterise the ageing process, and collectively, may be key determinants of the ageing trajectory. These include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intercellular communication. Healthier dietary patterns reduce the risk of age-related diseases and increase longevity and may influence positively one or more of these hallmarks. The Mediterranean dietary pattern (MedDiet) is a plant-based eating pattern that was typical of countries such as Greece, Spain, and Italy pre-globalisation of the food system and which is associated with better health during ageing. Here we review the potential effects of a MedDiet on each of the nine hallmarks of ageing, and provide evidence that the MedDiet as a whole, or individual elements of this dietary pattern, may influence each hallmark positively—effects which may contribute to the beneficial effects of this dietary pattern on age-related disease risk and longevity. We also highlight potential avenues for future research.
AB - Ageing is a multifactorial process associated with reduced function and increased risk of morbidity and mortality. Recently, nine cellular and molecular hallmarks of ageing have been identified, which characterise the ageing process, and collectively, may be key determinants of the ageing trajectory. These include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intercellular communication. Healthier dietary patterns reduce the risk of age-related diseases and increase longevity and may influence positively one or more of these hallmarks. The Mediterranean dietary pattern (MedDiet) is a plant-based eating pattern that was typical of countries such as Greece, Spain, and Italy pre-globalisation of the food system and which is associated with better health during ageing. Here we review the potential effects of a MedDiet on each of the nine hallmarks of ageing, and provide evidence that the MedDiet as a whole, or individual elements of this dietary pattern, may influence each hallmark positively—effects which may contribute to the beneficial effects of this dietary pattern on age-related disease risk and longevity. We also highlight potential avenues for future research.
KW - ageing
KW - biomarkers
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=85099957285&partnerID=8YFLogxK
U2 - 10.1038/s41430-020-00841-x
DO - 10.1038/s41430-020-00841-x
M3 - Review article
C2 - 33514872
AN - SCOPUS:85099957285
SN - 0954-3007
VL - 75
SP - 1176
EP - 1192
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
IS - 8
ER -