Metalloproteins and metal sensing

Kevin J. Waldron; Julian C. Rutherford; Dianne Ford; Nigel J. Robinson

doi:10.1038/nature08300

Metalloproteins and metal sensing

Kevin J. Waldron, Julian C. Rutherford, Dianne Ford, Nigel J. Robinson

Research output: Contribution to journal › Review article › peer-review

1003 Citations (Scopus)

Abstract

Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal-protein partnership arose and how it is maintained. Metal availability provides part of the explanation, and has changed over geological time and varies between habitats but is held within vital limits in cells. Such homeostasis needs metal sensors, and there is an ongoing search to discover the metal-sensing mechanisms. For metalloproteins to acquire the right metals, metal sensors must correctly distinguish between the inorganic elements.

Original language	English
Pages (from-to)	823-830
Number of pages	8
Journal	Nature
Volume	460
Issue number	7257
Early online date	12 Aug 2009
DOIs	https://doi.org/10.1038/nature08300
Publication status	Published - 13 Aug 2009
Externally published	Yes

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10.1038/nature08300

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Metalloproteins and metal sensing

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