Metalloproteins and metal sensing

Kevin J. Waldron, Julian C. Rutherford, Dianne Ford, Nigel J. Robinson

Research output: Contribution to journalReview articlepeer-review

709 Citations (Scopus)

Abstract

Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal-protein partnership arose and how it is maintained. Metal availability provides part of the explanation, and has changed over geological time and varies between habitats but is held within vital limits in cells. Such homeostasis needs metal sensors, and there is an ongoing search to discover the metal-sensing mechanisms. For metalloproteins to acquire the right metals, metal sensors must correctly distinguish between the inorganic elements.

Original languageEnglish
Pages (from-to)823-830
Number of pages8
JournalNature
Volume460
Issue number7257
Early online date12 Aug 2009
DOIs
Publication statusPublished - 13 Aug 2009
Externally publishedYes

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