Microwave-assisted domino reactions of propargylamines with isothiocyanates: selective synthesis of 2-aminothiazoles and 2-amino-4-methylenethiazolines

Daniele Castagnolo, Nicolò Scalacci, Chiara Pelloja, Marco Radi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A simple and versatile microwave-assisted protocol for the synthesis of 2-aminothiazoles has been developed. The domino reaction of propargylamines and isothiocyanates in the presence of catalytic PTSA leads to the selective synthesis of 2-aminothiazoles at temperatures above 130 °C and in a few minutes. The same reaction carried out at lower temperatures leads to the formation of the tautomeric 2-amino-4-methylenethiazolines.
Original languageEnglish
Pages (from-to)1883-1887
JournalSynlett
Volume27
Issue number12
Early online date7 Apr 2016
DOIs
Publication statusPublished - 8 Jul 2016

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