TY - JOUR
T1 - Mitochondrial Homeostasis and Cellular Senescence
AU - Vasileiou, Panagiotis V. S.
AU - Evangelou, Konstantinos
AU - Vlasis, Konstantinos
AU - Fildisis, Georgios
AU - Panayiotidis, Mihalis I.
AU - Chronopoulos, Efstathios
AU - Passias, Panagiotis-Georgios
AU - Kouloukoussa, Mirsini
AU - Gorgoulis, Vassilis G.
AU - Havaki, Sophia
PY - 2019/7/6
Y1 - 2019/7/6
N2 - Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senescence. On the other hand, impaired mitostasis has been suggested to induce cellular senescence. This review aims to provide an overview of homeostatic mechanisms operating within mitochondria and a comprehensive insight into the interplay between cellular senescence and mitochondrial dysfunction.
AB - Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senescence. On the other hand, impaired mitostasis has been suggested to induce cellular senescence. This review aims to provide an overview of homeostatic mechanisms operating within mitochondria and a comprehensive insight into the interplay between cellular senescence and mitochondrial dysfunction.
KW - cellular senescence
KW - mitochondria
KW - mitostasis
KW - mitochondrial dynamics
UR - https://www.scopus.com/pages/publications/85073516174
U2 - 10.3390/cells8070686
DO - 10.3390/cells8070686
M3 - Article
SN - 2073-4409
VL - 8
JO - Cells
JF - Cells
IS - 7
M1 - 686
ER -