Mitochondrial signalling and homeostasis: from cell biology to neurological disease

Jack J. Collier*, Monika Oláhová, Thomas G. McWilliams, Robert W. Taylor

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)
14 Downloads (Pure)

Abstract

Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have primarily focussed on the role of mitochondria in neuronal energy metabolism. However, progress in understanding the etiological nature of emerging mitochondrial functions has yielded new ideas about the mitochondrial basis of neurological disease. Studies aimed at deciphering how mitochondria signal through interorganellar contacts, vesicular trafficking, and metabolic transmission have revealed that mitochondrial regulation of immunometabolism, cell death, organelle dynamics, and neuroimmune interplay are critical determinants of neural health. Moreover, the homeostatic mechanisms that exist to protect mitochondrial health through turnover via nanoscale proteostasis and lysosomal degradation have become integrated within mitochondrial signalling pathways to support metabolic plasticity and stress responses in the nervous system. This review highlights how these distinct mitochondrial pathways converge to influence neurological health and contribute to disease pathology.

Original languageEnglish
Pages (from-to)137-152
Number of pages16
JournalTrends in Neurosciences
Volume46
Issue number2
Early online date10 Jan 2023
DOIs
Publication statusPublished - 1 Feb 2023
Externally publishedYes

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