Model for a population-based microbial oscillator

Angel Goñi-Moreno*, Martyn Amos

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Genetic oscillators are a major theme of interest in the emerging field of synthetic biology. Until recently, most work has been carried out using intra-cellular oscillators, but this approach restricts the broader applicability of such systems. Motivated by a desire to develop large-scale, spatially distributed cell-based computational systems, we present an initial design for a population-level oscillator which uses three different bacterial strains. Our system is based on the client-server model familiar to computer science, and uses quorum sensing for communication between nodes. Importantly, it is robust to perturbation and noise. We present the results of extensive in silico simulation tests, which confirm the feasibility of our design.

Original languageEnglish
Pages (from-to)286-294
Number of pages9
JournalBioSystems
Volume105
Issue number3
Early online date6 Jun 2011
DOIs
Publication statusPublished - 1 Sep 2011

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