@article{4c24b37481ce48bd8001424240806995,
title = "Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions",
abstract = "A recent workshop titled “Developing Models to Study Polymicrobial Infections,” sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of persons with cystic fibrosis (CF). The workshop gathered 35+ investigators over two virtual sessions. Here, we present the findings of this workshop, summarize some of the challenges involved with developing such models, and suggest three frameworks to tackle this complex problem. The frameworks proposed here, we believe, could be generally useful in developing new model systems for other infectious diseases. Developing and validating new approaches to study the complex polymicrobial communities in the CF airway could open windows to new therapeutics to treat these recalcitrant infections, as well as uncovering organizing principles applicable to chronic polymicrobial infections more generally.",
keywords = "cysticfibrosis, models, polymicrobial, airway, chronic infection",
author = "George O'Toole and Aur{\'e}lie Crabb{\'e} and Rolf K{\"u}mmerli and LiPuma, {John J.} and Bomberger, {Jennifer M.} and Davies, {Jane C.} and Dominique Limoli and Phelan, {Vanessa V.} and Bliska, {James B.} and DePas, {William H.} and Dietrich, {Lars E.} and Hampton, {Thomas H.} and Ryan Hunter and Khursigara, {Cezar M.} and Alex Price-Whelan and Alix Ashare and Cramer, {Robert A.} and Goldberg, {Joanna B.} and Freya Harrison and Hogan, {Deborah A.} and Henson, {Michael A.} and Madden, {Dean R.} and Mayers, {Jared R.} and Carey Nadell and Dianne Newman and Alice Prince and Rivett, {Damian W.} and Schwartzman, {Joseph D.} and Daniel Schultz and Sheppard, {Donald C.} and Smyth, {Alan R.} and Spero, {Melanie A.} and Stanton, {Bruce A.} and Turner, {Paul E.} and {van der Gast}, Chris and Whelan, {Fiona J.} and Rachel Whittaker and Katrine Whiteson",
note = "Funding infromation: Research funded by HHS | National Institutes of Health (P30-DK117469), Cystic Fibrosis Foundation (STANTO19R0), HHS, National Institutes of Health (1R01HL152190), Cystic Fibrosis Foundation (CRAMER19GO), Gouvernement du Canada, Canadian Institutes of Health Research (PJT 156111), HHS, National Institutes of Health (R35GM128690), HHS, National Institutes of Health (R01-DK104847), HHS, National Institutes of Health (R01-AI127548), Cystic Fibrosis Foundation (TURNER19PO), HHS, National Institutes of Health (R01 HL136919), Cystic Fibrosis Foundation (ASHARE21G0), HHS, National Institutes of Health (R35 HL18500), HHS, National Institutes of Health (P20 GM130454-02), National Institute for Health Research (NIHR Systematic Reviews Programm), Cystic Fibrosis Foundation (WHITEL20A0), HHS, National Institutes of Health (R01AI103369), University of Nottingham (University of Nottingham Anne McLaren Fellowship), Swiss National Science Foundation (31003A_182499), UKRI, Medical Research Council (MR/R001898/1), HHS, National Institutes of Health (R01 HL151385), HHS, National Institutes of Health (R01 AI155424), Cystic Fibrosis Foundation (BOMBER21R3), Cystic Fibrosis Foundation (SPERO19F0), HHS, National Institutes of Health (R01 HL136647), Paul G. Allen Family Foundation (Paul G. Allen Frontiers Investigator Award), National Institute for Health Research (mperial BRC and Senior Investigator Award), Cystic Fibrosis Trust (VIA 078), Gouvernement du Canada, Canadian Institutes of Health Research (FDN-159902), Cystic Fibrosis Foundation (LIMOLI19R3), Cystic Fibrosis Trust (VIA 077), Cystic Fibrosis Foundation (BOMBER18G0),",
year = "2021",
month = oct,
day = "26",
doi = "10.1128/mbio.01763-21",
language = "English",
volume = "12",
pages = "1--8",
journal = "mBio",
issn = "2161-2129",
publisher = "American Society for Microbiology",
number = "5",
}
