Modelling of Tirapazamine effects on solid tumour morphology

Nabila Kazmi, Alamgir Hossain, Roger Phillips

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Bioreductive drugs are in clinical practice to exploit the resistance from tumour microenvironments especially in the hypoxic region of tumour. We pre-sented a tumour treatment model to capture the pharmacology of one of the most prominent bioreductive drugs, Tirapazamine (TPZ) which is in clinical trials I and II. We calculated solid tumour mass in our previous work and then integrated that model with TPZ infusion. We calculated TPZ cytotoxicity, concentration, penetra-tion with increasing distance from blood vessel and offered resistance from micro-environments for drug penetration inside the tumour while considering each cell as an individual entity. The impact of these factors on tumour morphology is also showed to see the drug behaviour inside animals/humans tumours. We maintained the heterogeneity factors in presented model as observed in real tumour mass es-pecially in terms of cells proliferation, cell movement, extracellular matrix (ECM) interaction, and the gradients of partial oxygen pressure (pO2) inside tumour cells during the whole growth and treatment activity. The results suggest that TPZ high concentration in combination with chemotherapy should be given to get maximum abnormal cell killing. This model can be a good choice for oncologists and re-searchers to explore more about TPZ action inside solid tumour.
    Original languageEnglish
    Pages (from-to)125-132
    JournalAdvances in Intelligent and Soft Computing
    Volume93
    Issue number2011
    DOIs
    Publication statusPublished - 2011
    EventAdvances in intelligent and soft computing -
    Duration: 1 Jan 2011 → …

    Fingerprint Dive into the research topics of 'Modelling of Tirapazamine effects on solid tumour morphology'. Together they form a unique fingerprint.

    Cite this