This study aims to examine the relationships of self-competence in death work (SC-DW) with meaning in life (MIL) and depression, particularly the moderating effects of MIL on the relationship between depression and SC-DW. A total of 151 helping professionals completed a questionnaire. SC-DW showed negative and positive significant associations with depression and MIL, respectively. MIL was the moderator between depression and SC-DW. At the same depression level, helping professionals who experienced a higher level of MIL indicated a higher level of SC-DW, and particularly a higher level of emotional competence in death work. Implications on supporting helping professionals are discussed.