Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

Anita Toscani; Caterina Risi; Gary W. Black; Nicola L. Brown; Ali Shaaban; Nicholas J. Turner; Daniele Castagnolo

doi:10.1021/acscatal.8b02386

Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

Anita Toscani, Caterina Risi, Gary W. Black, Nicola L. Brown, Ali Shaaban, Nicholas J. Turner, Daniele Castagnolo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ ¹⁹F NMR.

Original language	English
Pages (from-to)	8781-8787
Number of pages	7
Journal	ACS Catalysis
Volume	8
Issue number	9
Early online date	7 Aug 2018
DOIs	https://doi.org/10.1021/acscatal.8b02386
Publication status	Published - 7 Sept 2018

Keywords

aromatization
biocatalysis
in situ NMR
MAO-N
pyridine
tetrahydropyridine

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title = "Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines",

abstract = "A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.",

keywords = "aromatization, biocatalysis, in situ NMR, MAO-N, pyridine, tetrahydropyridine",

author = "Anita Toscani and Caterina Risi and Black, {Gary W.} and Brown, {Nicola L.} and Ali Shaaban and Turner, {Nicholas J.} and Daniele Castagnolo",

year = "2018",

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T1 - Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

AU - Toscani, Anita

AU - Risi, Caterina

AU - Black, Gary W.

AU - Brown, Nicola L.

AU - Shaaban, Ali

AU - Turner, Nicholas J.

AU - Castagnolo, Daniele

PY - 2018/9/7

Y1 - 2018/9/7

N2 - A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.

AB - A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.

KW - aromatization

KW - biocatalysis

KW - in situ NMR

KW - MAO-N

KW - pyridine

KW - tetrahydropyridine

U2 - 10.1021/acscatal.8b02386

DO - 10.1021/acscatal.8b02386

M3 - Article

AN - SCOPUS:85052371873

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SP - 8781

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JO - ACS Catalysis

JF - ACS Catalysis

IS - 9

ER -

Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

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Keywords

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