Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

Anita Toscani, Caterina Risi, Gary W. Black, Nicola L. Brown, Ali Shaaban, Nicholas J. Turner, Daniele Castagnolo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)
7 Downloads (Pure)

Abstract

A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.

Original languageEnglish
Pages (from-to)8781-8787
Number of pages7
JournalACS Catalysis
Volume8
Issue number9
Early online date7 Aug 2018
DOIs
Publication statusPublished - 7 Sep 2018

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