Nocardichelins A and B, new siderophores from Nocardia strain Acta 3026

Kathrin Schneider, Ilona Rose, Sabaratnam Vikineswary, Amanda Jones, Michael Goodfellow, Graeme Nicholson, Winfried Beil, Roderich Süssmuth, Hans-Peter Fiedler

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

An actinomycete, strain Acta 3026, isolated from mangrove soil was characterized and found to belong to the genus Nocardia. The strain produces two new cytotoxic metabolites, nocardichelins A (1) and B (2). Each of the compounds strongly inhibited human cell lines from gastric adenocarcinoma, breast carcinoma, and hepatocellular carcinoma with GI50 values in a low micromolar to nanomolar range. The structural characterization of the compounds was performed by mass spectrometry and NMR spectroscopy. The nocardichelins represent a new group of siderophores that combine the structural elements of mycobactin-type siderophores from mycobacteria and hydroxamate-type siderophores (desferrioxamine B) produced by streptomycetes. The chromazurol S assay, characteristic for iron(III) complexation, was positive, confirming the role as a siderophore.
Original languageEnglish
Pages (from-to)932-935
JournalJournal of Natural Products
Volume70
Issue number6
DOIs
Publication statusPublished - 2007

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