Nocardichelins A and B, new siderophores from Nocardia strain Acta 3026

Kathrin Schneider; Ilona Rose; Sabaratnam Vikineswary; Amanda Jones; Michael Goodfellow; Graeme Nicholson; Winfried Beil; Roderich Süssmuth; Hans-Peter Fiedler

doi:10.1021/np060612i

Nocardichelins A and B, new siderophores from Nocardia strain Acta 3026

Kathrin Schneider, Ilona Rose, Sabaratnam Vikineswary, Amanda Jones, Michael Goodfellow, Graeme Nicholson, Winfried Beil, Roderich Süssmuth, Hans-Peter Fiedler

Applied Sciences Department

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

An actinomycete, strain Acta 3026, isolated from mangrove soil was characterized and found to belong to the genus Nocardia. The strain produces two new cytotoxic metabolites, nocardichelins A (1) and B (2). Each of the compounds strongly inhibited human cell lines from gastric adenocarcinoma, breast carcinoma, and hepatocellular carcinoma with GI50 values in a low micromolar to nanomolar range. The structural characterization of the compounds was performed by mass spectrometry and NMR spectroscopy. The nocardichelins represent a new group of siderophores that combine the structural elements of mycobactin-type siderophores from mycobacteria and hydroxamate-type siderophores (desferrioxamine B) produced by streptomycetes. The chromazurol S assay, characteristic for iron(III) complexation, was positive, confirming the role as a siderophore.

Original language	English
Pages (from-to)	932-935
Journal	Journal of Natural Products
Volume	70
Issue number	6
DOIs	https://doi.org/10.1021/np060612i
Publication status	Published - 2007

Keywords

siderophores
nocardia

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np060612i

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title = "Nocardichelins A and B, new siderophores from Nocardia strain Acta 3026",

abstract = "An actinomycete, strain Acta 3026, isolated from mangrove soil was characterized and found to belong to the genus Nocardia. The strain produces two new cytotoxic metabolites, nocardichelins A (1) and B (2). Each of the compounds strongly inhibited human cell lines from gastric adenocarcinoma, breast carcinoma, and hepatocellular carcinoma with GI50 values in a low micromolar to nanomolar range. The structural characterization of the compounds was performed by mass spectrometry and NMR spectroscopy. The nocardichelins represent a new group of siderophores that combine the structural elements of mycobactin-type siderophores from mycobacteria and hydroxamate-type siderophores (desferrioxamine B) produced by streptomycetes. The chromazurol S assay, characteristic for iron(III) complexation, was positive, confirming the role as a siderophore.",

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author = "Kathrin Schneider and Ilona Rose and Sabaratnam Vikineswary and Amanda Jones and Michael Goodfellow and Graeme Nicholson and Winfried Beil and Roderich S{\"u}ssmuth and Hans-Peter Fiedler",

year = "2007",

doi = "10.1021/np060612i",

language = "English",

volume = "70",

pages = "932--935",

journal = "Journal of Natural Products",

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TY - JOUR

T1 - Nocardichelins A and B, new siderophores from Nocardia strain Acta 3026

AU - Schneider, Kathrin

AU - Rose, Ilona

AU - Vikineswary, Sabaratnam

AU - Jones, Amanda

AU - Goodfellow, Michael

AU - Nicholson, Graeme

AU - Beil, Winfried

AU - Süssmuth, Roderich

AU - Fiedler, Hans-Peter

PY - 2007

Y1 - 2007

N2 - An actinomycete, strain Acta 3026, isolated from mangrove soil was characterized and found to belong to the genus Nocardia. The strain produces two new cytotoxic metabolites, nocardichelins A (1) and B (2). Each of the compounds strongly inhibited human cell lines from gastric adenocarcinoma, breast carcinoma, and hepatocellular carcinoma with GI50 values in a low micromolar to nanomolar range. The structural characterization of the compounds was performed by mass spectrometry and NMR spectroscopy. The nocardichelins represent a new group of siderophores that combine the structural elements of mycobactin-type siderophores from mycobacteria and hydroxamate-type siderophores (desferrioxamine B) produced by streptomycetes. The chromazurol S assay, characteristic for iron(III) complexation, was positive, confirming the role as a siderophore.

AB - An actinomycete, strain Acta 3026, isolated from mangrove soil was characterized and found to belong to the genus Nocardia. The strain produces two new cytotoxic metabolites, nocardichelins A (1) and B (2). Each of the compounds strongly inhibited human cell lines from gastric adenocarcinoma, breast carcinoma, and hepatocellular carcinoma with GI50 values in a low micromolar to nanomolar range. The structural characterization of the compounds was performed by mass spectrometry and NMR spectroscopy. The nocardichelins represent a new group of siderophores that combine the structural elements of mycobactin-type siderophores from mycobacteria and hydroxamate-type siderophores (desferrioxamine B) produced by streptomycetes. The chromazurol S assay, characteristic for iron(III) complexation, was positive, confirming the role as a siderophore.

KW - siderophores

KW - nocardia

U2 - 10.1021/np060612i

DO - 10.1021/np060612i

M3 - Article

SN - 0163-3864

VL - 70

SP - 932

EP - 935

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 6

ER -

Nocardichelins A and B, new siderophores from Nocardia strain Acta 3026

Abstract

Keywords

UN SDGs

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