TY - PAT
T1 - Novel peptidase substrates
AU - Fabrega, Olivier
AU - James, Arthur
AU - Orenga, Sylvain
AU - Perry, John
AU - Salwatura, Vindhya
AU - Stanforth, Stephen
PY - 2011
Y1 - 2011
N2 - The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: according to which: Y1 is a peptide, H or an alkyl W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof n = 0, 1 or 2 X is NR, CZ5Z6, S or O, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic, Z5 and Z6 being an alkyl Y is N or N+R, R being alkyl, aralkyl, aryl, alkanoic or alkylsulphonic Z1, Z2, Z3 and Z4 being independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the carboxyl or sulphonyl esters or amides and salts thereof.
AB - The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: according to which: Y1 is a peptide, H or an alkyl W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof n = 0, 1 or 2 X is NR, CZ5Z6, S or O, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic, Z5 and Z6 being an alkyl Y is N or N+R, R being alkyl, aralkyl, aryl, alkanoic or alkylsulphonic Z1, Z2, Z3 and Z4 being independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the carboxyl or sulphonyl esters or amides and salts thereof.
M3 - Patent
ER -