Novel peptidase substrates

Olivier Fabrega (Inventor), Arthur James (Inventor), Sylvain Orenga (Inventor), John Perry (Inventor), Vindhya Salwatura (Inventor), Stephen Stanforth (Inventor)

Research output: Patent


The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: according to which: Y1 is a peptide, H or an alkyl W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof n = 0, 1 or 2 X is NR, CZ5Z6, S or O, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic, Z5 and Z6 being an alkyl Y is N or N+R, R being alkyl, aralkyl, aryl, alkanoic or alkylsulphonic Z1, Z2, Z3 and Z4 being independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the carboxyl or sulphonyl esters or amides and salts thereof.
Original languageEnglish
Publication statusPublished - 2011


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