Obesity decreases time to claudication and delays post-exercise hemodynamic recovery in elderly peripheral arterial disease patients

Raphael Mendes Ritti Dias; Cláudia Lúcia de Moraes Forjaz; Gabriel Grizzo Cucato; Luis Augusto Riani Costa; Lucas Caseri Câmara; Nelson Wolosker; Maria de Fátima Nunes Marucci

doi:10.1159/000155219

Obesity decreases time to claudication and delays post-exercise hemodynamic recovery in elderly peripheral arterial disease patients

Raphael Mendes Ritti Dias, Cláudia Lúcia de Moraes Forjaz, Gabriel Grizzo Cucato, Luis Augusto Riani Costa, Lucas Caseri Câmara, Nelson Wolosker, Maria de Fátima Nunes Marucci

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

BACKGROUND: Althoughobesity is usually observed in peripheral arterial disease (PAD) patients, the effects of the association between these diseases on walking capacity are not well documented.

OBJECTIVE: The main objectives of this study were to determine the effects of obesity on exercise tolerance and post-exercise hemodynamic recovery in elderly PAD patients.

METHODS: 46 patients with stable symptoms of intermittent claudication were classified according to their body mass index (BMI) into normal group (NOR) = BMI <28.0 and obese or in risk of obesity group (OBE) = BMI >or=28.0. All patients performed a progressive graded treadmill test. During exercise, ventilatory responses were evaluated and pre- and post-exercise ankle and arm blood pressures were measured.

RESULTS: Exercise tolerance and oxygen consumption at total walking time were similar between OBE and NOR. However, OBE showed a lower claudication time (309 +/- 151 vs. 459 +/- 272 s, p = 0.02) with a similar oxygen consumption at this time. In addition, OBE presented a longer time for ankle brachial index recovery after exercise (7.8 +/- 2.8 vs. 6.3 +/- 2.6 min, p = 0.02).

CONCLUSION: Obesity in elderly PAD patients decreased time to claudication, and delayed post-exercise hemodynamic recovery. These results suggest that muscle metabolic demand, and not total workload, is responsible for the start of the claudication and maximal exercise tolerance in PAD patients. Moreover, claudication duration might be responsible for the time needed to a complete hemodynamic recovery after exercise.

Original language	English
Pages (from-to)	21-6
Number of pages	7
Journal	Gerontology
Volume	55
Issue number	1
Early online date	11 Sept 2008
DOIs	https://doi.org/10.1159/000155219
Publication status	Published - Jan 2009
Externally published	Yes

Keywords

Aged
Exercise Test
Female
Hemodynamics
Humans
Intermittent Claudication/etiology
Male
Middle Aged
Obesity/complications
Oxygen Consumption
Peripheral Vascular Diseases/complications

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000155219

Cite this

@article{733d7f617fd74743a3715828de4a6cf9,

title = "Obesity decreases time to claudication and delays post-exercise hemodynamic recovery in elderly peripheral arterial disease patients",

abstract = "BACKGROUND: Althoughobesity is usually observed in peripheral arterial disease (PAD) patients, the effects of the association between these diseases on walking capacity are not well documented.OBJECTIVE: The main objectives of this study were to determine the effects of obesity on exercise tolerance and post-exercise hemodynamic recovery in elderly PAD patients.METHODS: 46 patients with stable symptoms of intermittent claudication were classified according to their body mass index (BMI) into normal group (NOR) = BMI <28.0 and obese or in risk of obesity group (OBE) = BMI >or=28.0. All patients performed a progressive graded treadmill test. During exercise, ventilatory responses were evaluated and pre- and post-exercise ankle and arm blood pressures were measured.RESULTS: Exercise tolerance and oxygen consumption at total walking time were similar between OBE and NOR. However, OBE showed a lower claudication time (309 +/- 151 vs. 459 +/- 272 s, p = 0.02) with a similar oxygen consumption at this time. In addition, OBE presented a longer time for ankle brachial index recovery after exercise (7.8 +/- 2.8 vs. 6.3 +/- 2.6 min, p = 0.02).CONCLUSION: Obesity in elderly PAD patients decreased time to claudication, and delayed post-exercise hemodynamic recovery. These results suggest that muscle metabolic demand, and not total workload, is responsible for the start of the claudication and maximal exercise tolerance in PAD patients. Moreover, claudication duration might be responsible for the time needed to a complete hemodynamic recovery after exercise.",

keywords = "Aged, Exercise Test, Female, Hemodynamics, Humans, Intermittent Claudication/etiology, Male, Middle Aged, Obesity/complications, Oxygen Consumption, Peripheral Vascular Diseases/complications",

author = "Dias, {Raphael Mendes Ritti} and Forjaz, {Cl{\'a}udia L{\'u}cia de Moraes} and Cucato, {Gabriel Grizzo} and Costa, {Luis Augusto Riani} and C{\^a}mara, {Lucas Caseri} and Nelson Wolosker and Marucci, {Maria de F{\'a}tima Nunes}",

year = "2009",

month = jan,

doi = "10.1159/000155219",

language = "English",

volume = "55",

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journal = "Gerontology",

issn = "0304-324X",

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T1 - Obesity decreases time to claudication and delays post-exercise hemodynamic recovery in elderly peripheral arterial disease patients

AU - Dias, Raphael Mendes Ritti

AU - Forjaz, Cláudia Lúcia de Moraes

AU - Cucato, Gabriel Grizzo

AU - Costa, Luis Augusto Riani

AU - Câmara, Lucas Caseri

AU - Wolosker, Nelson

AU - Marucci, Maria de Fátima Nunes

PY - 2009/1

Y1 - 2009/1

N2 - BACKGROUND: Althoughobesity is usually observed in peripheral arterial disease (PAD) patients, the effects of the association between these diseases on walking capacity are not well documented.OBJECTIVE: The main objectives of this study were to determine the effects of obesity on exercise tolerance and post-exercise hemodynamic recovery in elderly PAD patients.METHODS: 46 patients with stable symptoms of intermittent claudication were classified according to their body mass index (BMI) into normal group (NOR) = BMI <28.0 and obese or in risk of obesity group (OBE) = BMI >or=28.0. All patients performed a progressive graded treadmill test. During exercise, ventilatory responses were evaluated and pre- and post-exercise ankle and arm blood pressures were measured.RESULTS: Exercise tolerance and oxygen consumption at total walking time were similar between OBE and NOR. However, OBE showed a lower claudication time (309 +/- 151 vs. 459 +/- 272 s, p = 0.02) with a similar oxygen consumption at this time. In addition, OBE presented a longer time for ankle brachial index recovery after exercise (7.8 +/- 2.8 vs. 6.3 +/- 2.6 min, p = 0.02).CONCLUSION: Obesity in elderly PAD patients decreased time to claudication, and delayed post-exercise hemodynamic recovery. These results suggest that muscle metabolic demand, and not total workload, is responsible for the start of the claudication and maximal exercise tolerance in PAD patients. Moreover, claudication duration might be responsible for the time needed to a complete hemodynamic recovery after exercise.

AB - BACKGROUND: Althoughobesity is usually observed in peripheral arterial disease (PAD) patients, the effects of the association between these diseases on walking capacity are not well documented.OBJECTIVE: The main objectives of this study were to determine the effects of obesity on exercise tolerance and post-exercise hemodynamic recovery in elderly PAD patients.METHODS: 46 patients with stable symptoms of intermittent claudication were classified according to their body mass index (BMI) into normal group (NOR) = BMI <28.0 and obese or in risk of obesity group (OBE) = BMI >or=28.0. All patients performed a progressive graded treadmill test. During exercise, ventilatory responses were evaluated and pre- and post-exercise ankle and arm blood pressures were measured.RESULTS: Exercise tolerance and oxygen consumption at total walking time were similar between OBE and NOR. However, OBE showed a lower claudication time (309 +/- 151 vs. 459 +/- 272 s, p = 0.02) with a similar oxygen consumption at this time. In addition, OBE presented a longer time for ankle brachial index recovery after exercise (7.8 +/- 2.8 vs. 6.3 +/- 2.6 min, p = 0.02).CONCLUSION: Obesity in elderly PAD patients decreased time to claudication, and delayed post-exercise hemodynamic recovery. These results suggest that muscle metabolic demand, and not total workload, is responsible for the start of the claudication and maximal exercise tolerance in PAD patients. Moreover, claudication duration might be responsible for the time needed to a complete hemodynamic recovery after exercise.

KW - Aged

KW - Exercise Test

KW - Female

KW - Hemodynamics

KW - Humans

KW - Intermittent Claudication/etiology

KW - Male

KW - Middle Aged

KW - Obesity/complications

KW - Oxygen Consumption

KW - Peripheral Vascular Diseases/complications

U2 - 10.1159/000155219

DO - 10.1159/000155219

M3 - Article

C2 - 18784409

SN - 0304-324X

VL - 55

SP - 21

EP - 26

JO - Gerontology

JF - Gerontology

IS - 1

ER -

Obesity decreases time to claudication and delays post-exercise hemodynamic recovery in elderly peripheral arterial disease patients

Abstract

Keywords

UN SDGs

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