TY - JOUR
T1 - Obesity decreases time to claudication and delays post-exercise hemodynamic recovery in elderly peripheral arterial disease patients
AU - Dias, Raphael Mendes Ritti
AU - Forjaz, Cláudia Lúcia de Moraes
AU - Cucato, Gabriel Grizzo
AU - Costa, Luis Augusto Riani
AU - Câmara, Lucas Caseri
AU - Wolosker, Nelson
AU - Marucci, Maria de Fátima Nunes
N1 - (c) 2008 S. Karger AG, Basel.
PY - 2009/1
Y1 - 2009/1
N2 - BACKGROUND: Althoughobesity is usually observed in peripheral arterial disease (PAD) patients, the effects of the association between these diseases on walking capacity are not well documented.OBJECTIVE: The main objectives of this study were to determine the effects of obesity on exercise tolerance and post-exercise hemodynamic recovery in elderly PAD patients.METHODS: 46 patients with stable symptoms of intermittent claudication were classified according to their body mass index (BMI) into normal group (NOR) = BMI <28.0 and obese or in risk of obesity group (OBE) = BMI >or=28.0. All patients performed a progressive graded treadmill test. During exercise, ventilatory responses were evaluated and pre- and post-exercise ankle and arm blood pressures were measured.RESULTS: Exercise tolerance and oxygen consumption at total walking time were similar between OBE and NOR. However, OBE showed a lower claudication time (309 +/- 151 vs. 459 +/- 272 s, p = 0.02) with a similar oxygen consumption at this time. In addition, OBE presented a longer time for ankle brachial index recovery after exercise (7.8 +/- 2.8 vs. 6.3 +/- 2.6 min, p = 0.02).CONCLUSION: Obesity in elderly PAD patients decreased time to claudication, and delayed post-exercise hemodynamic recovery. These results suggest that muscle metabolic demand, and not total workload, is responsible for the start of the claudication and maximal exercise tolerance in PAD patients. Moreover, claudication duration might be responsible for the time needed to a complete hemodynamic recovery after exercise.
AB - BACKGROUND: Althoughobesity is usually observed in peripheral arterial disease (PAD) patients, the effects of the association between these diseases on walking capacity are not well documented.OBJECTIVE: The main objectives of this study were to determine the effects of obesity on exercise tolerance and post-exercise hemodynamic recovery in elderly PAD patients.METHODS: 46 patients with stable symptoms of intermittent claudication were classified according to their body mass index (BMI) into normal group (NOR) = BMI <28.0 and obese or in risk of obesity group (OBE) = BMI >or=28.0. All patients performed a progressive graded treadmill test. During exercise, ventilatory responses were evaluated and pre- and post-exercise ankle and arm blood pressures were measured.RESULTS: Exercise tolerance and oxygen consumption at total walking time were similar between OBE and NOR. However, OBE showed a lower claudication time (309 +/- 151 vs. 459 +/- 272 s, p = 0.02) with a similar oxygen consumption at this time. In addition, OBE presented a longer time for ankle brachial index recovery after exercise (7.8 +/- 2.8 vs. 6.3 +/- 2.6 min, p = 0.02).CONCLUSION: Obesity in elderly PAD patients decreased time to claudication, and delayed post-exercise hemodynamic recovery. These results suggest that muscle metabolic demand, and not total workload, is responsible for the start of the claudication and maximal exercise tolerance in PAD patients. Moreover, claudication duration might be responsible for the time needed to a complete hemodynamic recovery after exercise.
KW - Aged
KW - Exercise Test
KW - Female
KW - Hemodynamics
KW - Humans
KW - Intermittent Claudication/etiology
KW - Male
KW - Middle Aged
KW - Obesity/complications
KW - Oxygen Consumption
KW - Peripheral Vascular Diseases/complications
U2 - 10.1159/000155219
DO - 10.1159/000155219
M3 - Article
C2 - 18784409
VL - 55
SP - 21
EP - 26
JO - Gerontology
JF - Gerontology
SN - 0304-324X
IS - 1
ER -
