Object Burying Test for Assessment of Obsessive Compulsive Behaviors in Mice

Ann Katrin Kraeuter, Paul C. Guest, Zoltán Sarnyai

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Obsessive-compulsive disorder (OCD) can occur in several psychiatric illnesses such as autism spectrum disorders (ASD) and it is more prevalent in children. This condition is characterized by repeated and apparently meaningless behaviors such as frequent hand washing, counting, tapping, and rocking. This can disrupt normal socialization and in some cases lead to self-harm. Therefore there is interest in developing more effective therapies for individuals suffering from these conditions. This chapter describes how to conduct the mouse marble burying test as a sensitive measure of compulsive behaviors.
Original languageEnglish
Title of host publicationPre-Clinical Models
Subtitle of host publicationTechniques and Protocols
EditorsPaul C. Guest
Place of PublicationNew York
PublisherHumana Press Inc.
Chapter6
Pages81-85
Number of pages5
ISBN (Electronic)9781493989942
ISBN (Print)9781493989935
DOIs
Publication statusPublished - 2019
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1916

Keywords

  • Autism spectrum disorder
  • Behavior
  • Marble burying
  • Mouse
  • Obsessive-compulsive disorder

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