Obstructive sleep apnea does not impair cardiorespiratory responses to progressive exercise performed until exhaustion in hypertensive elderly

Bruno Teixeira Barbosa; Amilton da Cruz Santos; Murillo Frazão; Tulio Rocha Petrucci; Gabriel Grizzo Cucato; Adriana Oliveira Sarmento; Eduardo D S Freitas; Anna Myrna Jaguaribe de Lima; Maria do Socorro Brasileiro-Santos

doi:10.1007/s11325-017-1557-7

Obstructive sleep apnea does not impair cardiorespiratory responses to progressive exercise performed until exhaustion in hypertensive elderly

Bruno Teixeira Barbosa, Amilton da Cruz Santos, Murillo Frazão, Tulio Rocha Petrucci, Gabriel Grizzo Cucato, Adriana Oliveira Sarmento, Eduardo D S Freitas, Anna Myrna Jaguaribe de Lima, Maria do Socorro Brasileiro-Santos

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

BACKGROUND: Elderly people have a high prevalence to systemic arterial hypertension (SAH) and obstructive sleep apnea (OSA). Both comorbidities are closely associated and inflict damage on cardiorespiratory capacity.

METHODS: In order to assess cardiorespiratory responses to the cardiopulmonary exercise test (CPET) among hypertensive elderly with OSA, we enrolled 28 subjects into two different groups: without OSA (No-OSA: apnea/hypopnea index (AHI) < 5 events/h; n = 15) and with OSA (OSA: AHI ≥ 15 events/h; n = 13). All subjects underwent CPET and polysomnographic assessments. After normality and homogeneity evaluations, independent t test and Pearson's correlation were performed. The significance level employed was p ≤ 0.05.

RESULTS: Hypertensive elderly with OSA presented lower heart rate recovery (HRR) in the second minute (HRR2) in relation to the No-OSA group. A negative correlation between AHI and ventilation (VE) (r = -0.63, p = 0.02) was found in polysomnography and CPET data comparisons, and oxygen saturation (O2S) levels significantly correlated with VE/VCO2slope (r = 0.66, p = 0.01); in addition, OSA group presented a positive correlation between oxygen consumption and O2S (r = 0.60, p = 0.02), unlike the no-OSA group.

CONCLUSIONS: OSA does not affect the CPET variables in hypertensive elderly, but it attenuates the HRR2. The association between O2S during sleep with ventilatory responses probably occurs due to the adaptations in the oxygen transport system unleashed via mechanical respiratory feedback; thus, it has been identified that OSA compromises the oxygen supply in hypertensive elderly.

Original language	English
Pages (from-to)	431-437
Number of pages	7
Journal	Sleep and Breathing
Volume	22
Issue number	2
Early online date	24 Aug 2017
DOIs	https://doi.org/10.1007/s11325-017-1557-7
Publication status	Published - 1 May 2018
Externally published	Yes

Keywords

Aged
Brazil
Exercise/physiology
Fatigue/physiopathology
Female
Heart/physiology
Humans
Hypertension/complications
Male
Polysomnography
Respiration
Sleep Apnea, Obstructive/complications

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10.1007/s11325-017-1557-7

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Barbosa, B. T., da Cruz Santos, A., Frazão, M., Petrucci, T. R., Cucato, G. G., Sarmento, A. O., Freitas, E. D. S., de Lima, A. M. J., & Brasileiro-Santos, M. D. S. (2018). Obstructive sleep apnea does not impair cardiorespiratory responses to progressive exercise performed until exhaustion in hypertensive elderly. Sleep and Breathing, 22(2), 431-437. https://doi.org/10.1007/s11325-017-1557-7

@article{2497eae21c334f89a24489fc510b4cd4,

title = "Obstructive sleep apnea does not impair cardiorespiratory responses to progressive exercise performed until exhaustion in hypertensive elderly",

abstract = "BACKGROUND: Elderly people have a high prevalence to systemic arterial hypertension (SAH) and obstructive sleep apnea (OSA). Both comorbidities are closely associated and inflict damage on cardiorespiratory capacity.METHODS: In order to assess cardiorespiratory responses to the cardiopulmonary exercise test (CPET) among hypertensive elderly with OSA, we enrolled 28 subjects into two different groups: without OSA (No-OSA: apnea/hypopnea index (AHI) < 5 events/h; n = 15) and with OSA (OSA: AHI ≥ 15 events/h; n = 13). All subjects underwent CPET and polysomnographic assessments. After normality and homogeneity evaluations, independent t test and Pearson's correlation were performed. The significance level employed was p ≤ 0.05.RESULTS: Hypertensive elderly with OSA presented lower heart rate recovery (HRR) in the second minute (HRR2) in relation to the No-OSA group. A negative correlation between AHI and ventilation (VE) (r = -0.63, p = 0.02) was found in polysomnography and CPET data comparisons, and oxygen saturation (O2S) levels significantly correlated with VE/VCO2slope (r = 0.66, p = 0.01); in addition, OSA group presented a positive correlation between oxygen consumption and O2S (r = 0.60, p = 0.02), unlike the no-OSA group.CONCLUSIONS: OSA does not affect the CPET variables in hypertensive elderly, but it attenuates the HRR2. The association between O2S during sleep with ventilatory responses probably occurs due to the adaptations in the oxygen transport system unleashed via mechanical respiratory feedback; thus, it has been identified that OSA compromises the oxygen supply in hypertensive elderly.",

keywords = "Aged, Brazil, Exercise/physiology, Fatigue/physiopathology, Female, Heart/physiology, Humans, Hypertension/complications, Male, Polysomnography, Respiration, Sleep Apnea, Obstructive/complications",

author = "Barbosa, {Bruno Teixeira} and {da Cruz Santos}, Amilton and Murillo Fraz{\~a}o and Petrucci, {Tulio Rocha} and Cucato, {Gabriel Grizzo} and Sarmento, {Adriana Oliveira} and Freitas, {Eduardo D S} and {de Lima}, {Anna Myrna Jaguaribe} and Brasileiro-Santos, {Maria do Socorro}",

year = "2018",

month = may,

day = "1",

doi = "10.1007/s11325-017-1557-7",

language = "English",

volume = "22",

pages = "431--437",

journal = "Sleep and Breathing",

issn = "1520-9512",

publisher = "Springer",

number = "2",

}

Barbosa, BT, da Cruz Santos, A, Frazão, M, Petrucci, TR, Cucato, GG, Sarmento, AO, Freitas, EDS, de Lima, AMJ & Brasileiro-Santos, MDS 2018, 'Obstructive sleep apnea does not impair cardiorespiratory responses to progressive exercise performed until exhaustion in hypertensive elderly', Sleep and Breathing, vol. 22, no. 2, pp. 431-437. https://doi.org/10.1007/s11325-017-1557-7

TY - JOUR

T1 - Obstructive sleep apnea does not impair cardiorespiratory responses to progressive exercise performed until exhaustion in hypertensive elderly

AU - Barbosa, Bruno Teixeira

AU - da Cruz Santos, Amilton

AU - Frazão, Murillo

AU - Petrucci, Tulio Rocha

AU - Cucato, Gabriel Grizzo

AU - Sarmento, Adriana Oliveira

AU - Freitas, Eduardo D S

AU - de Lima, Anna Myrna Jaguaribe

AU - Brasileiro-Santos, Maria do Socorro

PY - 2018/5/1

Y1 - 2018/5/1

N2 - BACKGROUND: Elderly people have a high prevalence to systemic arterial hypertension (SAH) and obstructive sleep apnea (OSA). Both comorbidities are closely associated and inflict damage on cardiorespiratory capacity.METHODS: In order to assess cardiorespiratory responses to the cardiopulmonary exercise test (CPET) among hypertensive elderly with OSA, we enrolled 28 subjects into two different groups: without OSA (No-OSA: apnea/hypopnea index (AHI) < 5 events/h; n = 15) and with OSA (OSA: AHI ≥ 15 events/h; n = 13). All subjects underwent CPET and polysomnographic assessments. After normality and homogeneity evaluations, independent t test and Pearson's correlation were performed. The significance level employed was p ≤ 0.05.RESULTS: Hypertensive elderly with OSA presented lower heart rate recovery (HRR) in the second minute (HRR2) in relation to the No-OSA group. A negative correlation between AHI and ventilation (VE) (r = -0.63, p = 0.02) was found in polysomnography and CPET data comparisons, and oxygen saturation (O2S) levels significantly correlated with VE/VCO2slope (r = 0.66, p = 0.01); in addition, OSA group presented a positive correlation between oxygen consumption and O2S (r = 0.60, p = 0.02), unlike the no-OSA group.CONCLUSIONS: OSA does not affect the CPET variables in hypertensive elderly, but it attenuates the HRR2. The association between O2S during sleep with ventilatory responses probably occurs due to the adaptations in the oxygen transport system unleashed via mechanical respiratory feedback; thus, it has been identified that OSA compromises the oxygen supply in hypertensive elderly.

AB - BACKGROUND: Elderly people have a high prevalence to systemic arterial hypertension (SAH) and obstructive sleep apnea (OSA). Both comorbidities are closely associated and inflict damage on cardiorespiratory capacity.METHODS: In order to assess cardiorespiratory responses to the cardiopulmonary exercise test (CPET) among hypertensive elderly with OSA, we enrolled 28 subjects into two different groups: without OSA (No-OSA: apnea/hypopnea index (AHI) < 5 events/h; n = 15) and with OSA (OSA: AHI ≥ 15 events/h; n = 13). All subjects underwent CPET and polysomnographic assessments. After normality and homogeneity evaluations, independent t test and Pearson's correlation were performed. The significance level employed was p ≤ 0.05.RESULTS: Hypertensive elderly with OSA presented lower heart rate recovery (HRR) in the second minute (HRR2) in relation to the No-OSA group. A negative correlation between AHI and ventilation (VE) (r = -0.63, p = 0.02) was found in polysomnography and CPET data comparisons, and oxygen saturation (O2S) levels significantly correlated with VE/VCO2slope (r = 0.66, p = 0.01); in addition, OSA group presented a positive correlation between oxygen consumption and O2S (r = 0.60, p = 0.02), unlike the no-OSA group.CONCLUSIONS: OSA does not affect the CPET variables in hypertensive elderly, but it attenuates the HRR2. The association between O2S during sleep with ventilatory responses probably occurs due to the adaptations in the oxygen transport system unleashed via mechanical respiratory feedback; thus, it has been identified that OSA compromises the oxygen supply in hypertensive elderly.

KW - Aged

KW - Brazil

KW - Exercise/physiology

KW - Fatigue/physiopathology

KW - Female

KW - Heart/physiology

KW - Humans

KW - Hypertension/complications

KW - Male

KW - Polysomnography

KW - Respiration

KW - Sleep Apnea, Obstructive/complications

U2 - 10.1007/s11325-017-1557-7

DO - 10.1007/s11325-017-1557-7

M3 - Article

C2 - 28840546

SN - 1520-9512

VL - 22

SP - 431

EP - 437

JO - Sleep and Breathing

JF - Sleep and Breathing

IS - 2

ER -

Obstructive sleep apnea does not impair cardiorespiratory responses to progressive exercise performed until exhaustion in hypertensive elderly

Abstract

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