Abstract
Hand in hand: The title transformation was achieved using a pair of sulfatases acting through inversion and retention of configuration on opposite substrate enantiomers. Using Pseudomonas aeruginosa arylsulfatase PAS with alkylsulfatase PISA1 in one-pot leads to sec-alcohols (80 to >99 % conversion) with 91 to greater than 99 % ee.
Original language | English |
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Pages (from-to) | 3277-3279 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 52 |
Issue number | 11 |
DOIs | |
Publication status | Published - 11 Mar 2013 |
Externally published | Yes |
Keywords
- alcohols
- biotransformations
- enzyme catalysis
- kinetic resolution
- synthetic methods