Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets

Georgina Xanthou, Themis Alissafi, Maria Semitekolou, D. C M Simoes, Erasmia Economidou, Mina Gaga, Bart N. Lambrecht, Clare M. Lloyd, Vily Panoutsakopoulou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

152 Citations (Scopus)

Abstract

Osteopontin (Opn) is important for T helper type 1 (TH1) immunity and autoimmunity. However, the role of this cytokine in T H2-mediated allergic disease as well as its effects on primary versus secondary antigenic encounters remain unclear. Here we demonstrate that OPN is expressed in the lungs of asthmatic individuals and that Opn-s, the secreted form of Opn, exerts opposing effects on mouse TH2 effector responses and subsequent allergic airway disease: pro-inflammatory at primary systemic sensitization, and anti-inflammatory during secondary pulmonary antigenic challenge. These effects of Opn-s are mainly mediated by the regulation of TH2-suppressing plasmacytoid dendritic cells (DCs) during primary sensitization and TH2-promoting conventional DCs during secondary antigenic challenge. Therapeutic administration of recombinant Opn during pulmonary secondary antigenic challenge decreased established TH2 responses and protected mice from allergic disease. These effects on T H2 allergic responses suggest that Opn-s is an important therapeutic target and provide new insight into its role in immunity.

Original languageEnglish
Pages (from-to)570-578
Number of pages9
JournalNature Medicine
Volume13
Issue number5
DOIs
Publication statusPublished - May 2007
Externally publishedYes

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