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P3R:Polymodal Palpebral Progressive Refinement via Symmetry Aware Latent Diffusion for Precision Guided Prediction of Postoperative Blepharoptosis Morphology

Shuaixuan Zhou*, Xingru Huang, Zhao Huang, Han Yang, Zhaoyang Xu, Huiyu Zhou, Guangyuan Zhang, Wenwen Tang, Wenbin Zhang, Xuan Zhang, Jin Liu, Zhiwen Zheng, Lixia Lou, Xiaoshuai Zhang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Blepharoptosis is a descent of the upper eyelid that can impair vision. In surgical planning, clinicians need accurate, anatomically aware forecasts of postoperative appearance. Prevailing approaches such as geometric modeling, linear regression on margin reflex distance 1, and generative adversarial networks either oversimplify dermal and muscular dynamics or lack reliable anatomical control. We introduce Polymodal Palpebral Progressive Refinement (P3R), a framework that fuses three complementary priors, (i) concise, clinician verifiable text descriptors embedded via Contrastive Language–Image Pretraining, (ii) ocular masks derived from the Segment Anything Model that confine edits to operative regions, and (iii) a symmetry corrected contour prior that transfers healthy side geometry to the affected eyelid. A multi head cross attention mechanism aligns textual and visual cues during denoising to preserve eyelid topology and iris exposure. On 44 pairs from 30 subjects, Polymodal Palpebral Progressive Refinement improves anatomical indices over strong baselines while maintaining high image fidelity, thereby supporting precision counseling and surgical decision making. The results highlight the need for symmetry aware, multimodal conditioning to meet submillimetric clinical requirements.
Original languageEnglish
Article number130527
Pages (from-to)1-20
Number of pages20
JournalExpert Systems with Applications
Volume304
Early online date3 Dec 2025
DOIs
Publication statusPublished - 1 Apr 2026

Keywords

  • Blepharoptosis
  • Latent diffusion model
  • Medical image synthesis
  • Multimodal fusion
  • Postoperative outcome prediction
  • Segment anything model

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