TY - JOUR
T1 - Pathways to cellular supremacy in biocomputing
AU - Grozinger, Lewis
AU - Amos, Martyn
AU - Gorochowski, Thomas
AU - Carbonell, Pablo
AU - Oyarzun, Diego
AU - Stoof, Ruud
AU - Fellermann, Harold
AU - Zuliani, Paulo
AU - Tas, Huseyin
AU - Goñi-Moreno, Angel
PY - 2019/12
Y1 - 2019/12
N2 - Synthetic biology uses living cells as the substrate for performing human-defined computations. Many current implementations of cellular computing are based on the “genetic circuit” metaphor, an approximation of the operation of silicon-based computers. Although this conceptual mapping has been relatively successful, we argue that it fundamentally limits the types of computation that may be engineered inside the cell, and fails to exploit the rich and diverse functionality available in natural living systems. We propose the notion of “cellular supremacy” to focus attention on domains in which biocomputing might offer superior performance over traditional computers. We consider potential pathways toward cellular supremacy, and suggest application areas in which it may be found.
AB - Synthetic biology uses living cells as the substrate for performing human-defined computations. Many current implementations of cellular computing are based on the “genetic circuit” metaphor, an approximation of the operation of silicon-based computers. Although this conceptual mapping has been relatively successful, we argue that it fundamentally limits the types of computation that may be engineered inside the cell, and fails to exploit the rich and diverse functionality available in natural living systems. We propose the notion of “cellular supremacy” to focus attention on domains in which biocomputing might offer superior performance over traditional computers. We consider potential pathways toward cellular supremacy, and suggest application areas in which it may be found.
UR - http://www.scopus.com/inward/record.url?scp=85075386386&partnerID=8YFLogxK
U2 - 10.1038/s41467-019-13232-z
DO - 10.1038/s41467-019-13232-z
M3 - Review article
C2 - 31748511
SN - 2041-1723
VL - 10
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5250
ER -