Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction: Central Role of Adiposity

Payman Zamani*, Elizabeth A. Proto, Jeremy A. Mazurek, Stuart B. Prenner, Kenneth B. Margulies, Raymond R. Townsend, Daniel P. Kelly, Zoltan Arany, David C. Poole, Peter D. Wagner, Julio A. Chirinos

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)
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Abstract

The aim of this study was to determine the arteriovenous oxygen content difference (ΔAVO2) in adult subjects with and without heart failure with preserved ejection fraction (HFpEF) during systemic and forearm exercise. Subjects with HFpEF had reduced ΔAVO2. Forearm diffusional conductance for oxygen, a lumped conductance parameter that incorporates all impediments to the movement of oxygen from red blood cells in skeletal muscle capillaries into the mitochondria within myocytes, was estimated. Forearm diffusional conductance for oxygen was not different among adults with HFpEF, those with hypertension, and healthy control subjects; therefore, diffusional conductance cannot explain the reduced forearm ΔAVO2. Instead, adiposity was strongly associated with ΔAVO2, suggesting an active role for adipose tissue in reducing exercise capacity in patients with HFpEF.

Original languageEnglish
Pages (from-to)211-225
Number of pages15
JournalJACC: Basic to Translational Science
Volume5
Issue number3
Early online date23 Mar 2020
DOIs
Publication statusPublished - Mar 2020
Externally publishedYes

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