Phylogenomic analyses of multidrug resistant Corynebacterium striatum strains isolated from patients in a tertiary care hospital in the UK

Vartul Sangal*, Emma C.L. Marrs, Andrew Nelson, John D. Perry

*Corresponding author for this work

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Corynebacterium striatum is an emerging nosocomial pathogen. This is the first report showing the presence of three distinct multidrug resistant lineages of C. striatum among patients in a UK hospital. The presence of ErmX, Tet(W), Bla and AmpC proteins, and mutations in gyrA gene are associated with the resistance to clindamycin, doxycycline, penicillin and moxifloxacin, respectively. These strains are equipped with several corynebacterial virulence genes including two SpaDEF-type and a novel pilus gene cluster, which needs further molecular characterisation. This study highlights a need of developing an active surveillance strategy for routine monitoring and preventing potential cross-transmission among susceptible patients. [Abstract copyright: © 2024. The Author(s).]
Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Early online date27 May 2024
Publication statusE-pub ahead of print - 27 May 2024

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