TY - JOUR
T1 - Phylogenomic analyses of multidrug resistant Corynebacterium striatum strains isolated from patients in a tertiary care hospital in the UK
AU - Sangal, Vartul
AU - Marrs, Emma C.L.
AU - Nelson, Andrew
AU - Perry, John D.
PY - 2024/7/1
Y1 - 2024/7/1
N2 - Corynebacterium striatum is an emerging nosocomial pathogen. This is the first report showing the presence of three distinct multidrug resistant lineages of C. striatum among patients in a UK hospital. The presence of ErmX, Tet(W), Bla and AmpC proteins, and mutations in gyrA gene are associated with the resistance to clindamycin, doxycycline, penicillin and moxifloxacin, respectively. These strains are equipped with several corynebacterial virulence genes including two SpaDEF-type and a novel pilus gene cluster, which needs further molecular characterisation. This study highlights a need of developing an active surveillance strategy for routine monitoring and preventing potential cross-transmission among susceptible patients.
AB - Corynebacterium striatum is an emerging nosocomial pathogen. This is the first report showing the presence of three distinct multidrug resistant lineages of C. striatum among patients in a UK hospital. The presence of ErmX, Tet(W), Bla and AmpC proteins, and mutations in gyrA gene are associated with the resistance to clindamycin, doxycycline, penicillin and moxifloxacin, respectively. These strains are equipped with several corynebacterial virulence genes including two SpaDEF-type and a novel pilus gene cluster, which needs further molecular characterisation. This study highlights a need of developing an active surveillance strategy for routine monitoring and preventing potential cross-transmission among susceptible patients.
KW - Antimicrobial resistance
KW - Corynebacterium striatum
KW - Nosocomial infection
KW - Patients
KW - Phylogenomic diversity
KW - Virulence
UR - http://www.scopus.com/inward/record.url?scp=85194530367&partnerID=8YFLogxK
U2 - 10.1007/s10096-024-04857-0
DO - 10.1007/s10096-024-04857-0
M3 - Article
C2 - 38801486
SN - 0934-9723
VL - 43
SP - 1495
EP - 1501
JO - European Journal of Clinical Microbiology and Infectious Diseases
JF - European Journal of Clinical Microbiology and Infectious Diseases
IS - 7
ER -