TY - JOUR
T1 - Phylogenomic characterisation of a novel corynebacterial species pathogenic to animals
AU - Möller, Jens
AU - Musella, Luca Musella
AU - Melnikov, Vyacheslav
AU - Geißdörfer, Walter
AU - Burkovski, Andreas
AU - Sangal, Vartul
PY - 2020/8/1
Y1 - 2020/8/1
N2 - The genus Corynebacterium includes species of biotechnological, medical and veterinary importance. An atypical C. ulcerans strain, W25, was recently isolated from a case of necrotizing lymphadenitis in a wild boar. In this study, we have analysed the genome sequence of this strain and compared the phenotypic and virulence properties with other corynebacterial pathogens. Phylogenomic analyses revealed that strain W25 belongs to a novel species along with PO100/5 and KL1196. The latter strains were isolated from a pig and a roe deer, respectively; hence, this species appears to be associated to animals. The isolate W25 is likely a non-toxigenic tox gene bearing strain and may have compromised abilities to adhere to pharyngeal and laryngeal epithelial cells due to potential loss of the gene functions in spaBC and spaDEF pilus gene clusters. A number of corynebacterial virulence genes are present including pld encoding phospholipase D. Therefore, this strain may be able to cause severe invasive infections in animals and zoonotic infections in humans.
AB - The genus Corynebacterium includes species of biotechnological, medical and veterinary importance. An atypical C. ulcerans strain, W25, was recently isolated from a case of necrotizing lymphadenitis in a wild boar. In this study, we have analysed the genome sequence of this strain and compared the phenotypic and virulence properties with other corynebacterial pathogens. Phylogenomic analyses revealed that strain W25 belongs to a novel species along with PO100/5 and KL1196. The latter strains were isolated from a pig and a roe deer, respectively; hence, this species appears to be associated to animals. The isolate W25 is likely a non-toxigenic tox gene bearing strain and may have compromised abilities to adhere to pharyngeal and laryngeal epithelial cells due to potential loss of the gene functions in spaBC and spaDEF pilus gene clusters. A number of corynebacterial virulence genes are present including pld encoding phospholipase D. Therefore, this strain may be able to cause severe invasive infections in animals and zoonotic infections in humans.
KW - Corynebacterium ulcerans
KW - Diphtheria
KW - NTTB
KW - Non-toxigenic
KW - Toxigenic
KW - Virulence
KW - Zoonotic
UR - http://www.scopus.com/inward/record.url?scp=85085966618&partnerID=8YFLogxK
U2 - 10.1007/s10482-020-01430-5
DO - 10.1007/s10482-020-01430-5
M3 - Article
C2 - 32500295
SN - 0003-6072
VL - 113
SP - 1225
EP - 1239
JO - Antonie van Leeuwenhoek
JF - Antonie van Leeuwenhoek
IS - 8
ER -