Physical activity levels and hepatic steatosis: A longitudinal follow-up study in adults

Aline Mendes Gerage, Raphael Mendes Ritti-Dias, P Babu Balagopal, Raquel Dilguerian de Oliveira Conceição, Daniel Umpierre, Raul D Santos, Gabriel Grizzo Cucato, Márcio Sommer Bittencourt

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


BACKGROUND AND AIM: This study aimed to evaluate the impact of physical activity (PA) on the course of hepatic steatosis (HS) in adults.

METHODS: Hepatic steatosis status (ultrasonography) and PA levels were evaluated in 5860 subjects at baseline and after approximately 2.5 years (range: 19-50 months). At follow up, possible exposures to different PA levels were those who remained inactive, became inactive, became active, and remained active. After follow up, subjects were then classified according to the four possible states (outcomes): "remained without HS," "developed HS" (subjects without HS at baseline), "remained with HS," or "reverted HS."

RESULTS: After multivariate adjustments, individuals without HS that became or remained physically active were less likely to develop HS compared with those who remained physically inactive (odds ratio = 0.75, P = 0.04 and 0.75, P = 0.03, respectively). Among those with HS at baseline, becoming and remaining physically active beneficially improved the HS status (odds ratio = 0.64, P = 0.01 and 0.66, P = 0.01, respectively). However, the significance was lost when adjusted for changes in body mass index.

CONCLUSION: Higher levels of PA were associated with prevention and treatment of HS, with evidence of effect mediation by changes in body mass index.

Original languageEnglish
Pages (from-to)741-746
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number3
Early online date22 Feb 2018
Publication statusPublished - 1 Mar 2018
Externally publishedYes


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