TY - JOUR
T1 - Physical assessment as a predictor of mortality in people with Parkinson's disease: a study over 7 years
AU - Gray, William
AU - Hildreth, Anthony
AU - Bilclough, Julie
AU - Wood, Brian
AU - Baker, Katherine
AU - Walker, Richard W.
PY - 2009/10
Y1 - 2009/10
N2 - The primary aim of this study was to ascertain whether a battery of physical function measures in a Parkinson's disease (PD) patient cohort predicted mortality status at 7-year follow-up. Secondary aims were establishing which specific tests were the most useful, and whether PD phenotype was a predictor. A retrospective correlation design was used in this study. A cohort of 109 PD patients underwent baseline physiotherapy assessment of gait, balance, posture, muscle strength, and ability to change postural set. We compared mortality status at 7-year follow-up and baseline physical assessment tests. Tinetti gait and balance scores, UPDRS score, 10-m walk test (time, velocity, and number of strides), posture in standing, lying to sitting, sitting to standing, getting up from floor assessments, and time to ascend and descend four steps were found to be statistically significant physical predictors of mortality at 7-year follow-up. In addition, age, sex, and mini-mental state examination were significant nonphysical predictors of mortality. Using Cox regression, a survival model was constructed with age, sex, and Tinetti gait score as independent predictors of mortality. The results of this study suggest that there is a link between reduced physical function and an increased mortality risk in PD populations. (c) 2009 Movement Disorders Society.
AB - The primary aim of this study was to ascertain whether a battery of physical function measures in a Parkinson's disease (PD) patient cohort predicted mortality status at 7-year follow-up. Secondary aims were establishing which specific tests were the most useful, and whether PD phenotype was a predictor. A retrospective correlation design was used in this study. A cohort of 109 PD patients underwent baseline physiotherapy assessment of gait, balance, posture, muscle strength, and ability to change postural set. We compared mortality status at 7-year follow-up and baseline physical assessment tests. Tinetti gait and balance scores, UPDRS score, 10-m walk test (time, velocity, and number of strides), posture in standing, lying to sitting, sitting to standing, getting up from floor assessments, and time to ascend and descend four steps were found to be statistically significant physical predictors of mortality at 7-year follow-up. In addition, age, sex, and mini-mental state examination were significant nonphysical predictors of mortality. Using Cox regression, a survival model was constructed with age, sex, and Tinetti gait score as independent predictors of mortality. The results of this study suggest that there is a link between reduced physical function and an increased mortality risk in PD populations. (c) 2009 Movement Disorders Society.
KW - Parkinson's disease
KW - physiotherapy
KW - physical therapy
KW - mortality
U2 - 10.1002/mds.22610
DO - 10.1002/mds.22610
M3 - Article
SN - 0885-3185
SN - 1531-8257
VL - 24
SP - 1934
EP - 1940
JO - Movement Disorders: Official Journal of the International Parkinson and Movement Disorder Society
JF - Movement Disorders: Official Journal of the International Parkinson and Movement Disorder Society
IS - 13
ER -