Physiological predictors of maximum treadmill walking performance in patients with intermittent claudication

Garry Tew, Shah Nawaz, Milica Blagojevic, Irena Zwierska, John Saxton

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

he purpose of this investigation was to identify physiological predictors of maximum treadmill walking performance (MWD) in patients with intermittent claudication. Forty-five claudicants performed a graded treadmill test to determine MWD, peak oxygen uptake, and gas exchange threshold. Calf muscle oxygenation (StO2) at 1 min and time to minimum StO2 were also measured using near-infrared spectroscopy. On other occasions, peak calf blood flow, resting ankle-brachial index, and pulmonary oxygen uptake kinetics during steady-state walking were assessed. A forward stepwise multiple regression analysis was performed to determine predictors of MWD. A regression model comprising time to minimum StO2, peak oxygen uptake, and StO2 at 1 min explained 64% of the variation in MWD. The results suggest that cardiopulmonary fitness and the ability to match oxygen delivery to metabolic demand are important determinants of walking performance in claudicants, and that certain near-infrared spectroscopy variables might be useful in studies that evaluate the mechanisms of clinical improvement with different treatment interventions.
Original languageEnglish
Pages (from-to)467-472
JournalInternational Journal of Sports Medicine
Volume30
Issue number6
DOIs
Publication statusPublished - 2009

Fingerprint Dive into the research topics of 'Physiological predictors of maximum treadmill walking performance in patients with intermittent claudication'. Together they form a unique fingerprint.

Cite this