Poor sleep quality and progression of gait impairment in an incident Parkinson's disease cohort

Seán O'Dowd, Brook Galna, Rosie Morris, Rachael A Lawson, Claire McDonald, Alison J Yarnall, David J Burn, Lynn Rochester, Kirstie N Anderson

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)
7 Downloads (Pure)

Abstract

Abnormal sleep may associate with cognitive decline in Parkinson's disease (PD). Furthermore, sleep dysfunction may associate with worse motor outcome. We hypothesised that PD patients with poor quality sleep would have greater progression in gait dysfunction, due to structural and functional overlap in networks subserving sleep and gait regulation. 12 PD patients and 12 age-matched controls completed longitudinal follow-up over 36 months. Poor sleep efficiency and greater sleep fragmentation correlated significantly with progression of step-width variability, a gait characteristic mediated by postural control, providing evidence that poor sleep in PD is associated with a more rapid deterioration in gait.

Original languageEnglish
Pages (from-to)465-470
Number of pages6
JournalJournal of Parkinson's Disease
Volume7
Issue number3
Early online date30 Jul 2017
DOIs
Publication statusPublished - 8 Aug 2017
Externally publishedYes

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