Poor sleep quality and progression of gait impairment in an incident Parkinson's disease cohort

Seán O'Dowd; Brook Galna; Rosie Morris; Rachael A Lawson; Claire McDonald; Alison J Yarnall; David J Burn; Lynn Rochester; Kirstie N Anderson

doi:10.3233/JPD-161062

Poor sleep quality and progression of gait impairment in an incident Parkinson's disease cohort

Seán O'Dowd, Brook Galna, Rosie Morris, Rachael A Lawson, Claire McDonald, Alison J Yarnall, David J Burn, Lynn Rochester, Kirstie N Anderson

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Abstract

Abnormal sleep may associate with cognitive decline in Parkinson's disease (PD). Furthermore, sleep dysfunction may associate with worse motor outcome. We hypothesised that PD patients with poor quality sleep would have greater progression in gait dysfunction, due to structural and functional overlap in networks subserving sleep and gait regulation. 12 PD patients and 12 age-matched controls completed longitudinal follow-up over 36 months. Poor sleep efficiency and greater sleep fragmentation correlated significantly with progression of step-width variability, a gait characteristic mediated by postural control, providing evidence that poor sleep in PD is associated with a more rapid deterioration in gait.

Original language	English
Pages (from-to)	465-470
Number of pages	6
Journal	Journal of Parkinson's Disease
Volume	7
Issue number	3
Early online date	30 Jul 2017
DOIs	https://doi.org/10.3233/JPD-161062
Publication status	Published - 8 Aug 2017
Externally published	Yes

Keywords

Aged
Cohort Studies
Disease Progression
Female
Gait Disorders, Neurologic/complications
Humans
Male
Middle Aged
Parkinson Disease/complications
Sleep Deprivation
Sleep Wake Disorders/complications

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10.3233/JPD-161062

Poor sleep quality and progression of gait impairment in an incident Parkinson's disease cohortAccepted author manuscript, 621 KB

https://eprint.ncl.ac.uk/239746

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abstract = "Abnormal sleep may associate with cognitive decline in Parkinson's disease (PD). Furthermore, sleep dysfunction may associate with worse motor outcome. We hypothesised that PD patients with poor quality sleep would have greater progression in gait dysfunction, due to structural and functional overlap in networks subserving sleep and gait regulation. 12 PD patients and 12 age-matched controls completed longitudinal follow-up over 36 months. Poor sleep efficiency and greater sleep fragmentation correlated significantly with progression of step-width variability, a gait characteristic mediated by postural control, providing evidence that poor sleep in PD is associated with a more rapid deterioration in gait.",

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AU - Yarnall, Alison J

AU - Burn, David J

AU - Rochester, Lynn

AU - Anderson, Kirstie N

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Poor sleep quality and progression of gait impairment in an incident Parkinson's disease cohort

Abstract

Keywords

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