TY - JOUR
T1 - Prevalence of BRCA mutation in breast and ovarian cancer among women in India
T2 - A systematic review and meta-analysis protocol
AU - Patra, Abhilash
AU - Ali, Syeda Sana
AU - Devi, Ng Marina
AU - Qadeer, Amatullah Sana
AU - Kamalakannan, Sureshkumar
AU - Nag, Shona
AU - Kulkarni, Shriniwas Subhash
AU - Rajappa, Senthil
AU - Hariharan, Nisha
AU - Pant, Hira Ballabh
AU - Agiwal, Varun
AU - A. Y., Nirupama
PY - 2024/7/16
Y1 - 2024/7/16
N2 - Purpose We present a methodically devised protocol for conducting a systematic review and metaanalysis aimed at ascertaining the prevalence of BReast CAncer gene (BRCA) mutations in breast and ovarian cancer (BOC) among women in India. The review will include cross-sectional, cohort, case-series, and registry-based studies focusing on females clinically diagnosed with any stage of BOC, tested for BRCA germline mutation and undergone any form of treatment. Methods A Cochrane literature search will be carried out to identify all the published and unpublished articles available in English from 2010 till date across various electronic databases including PubMed, Psych Info, SCI, Cochrane Central, Embase, Scopus, IND Med and Google Scholar. A step-by-step process will be followed to select all the relevant studies for final inclusion using Rayyan software. The selection process of the review will be reported based on Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA) checklist. The protocol has been registered in PROSPERO (ID: CRD42023463452). Joanna Briggs Institute Critical Appraisal Checklist will be used to evaluate the methodological quality of the included studies. The outcome measure will be the prevalence of BRCA1/2 gene mutation in this population. Meta-analysis will be performed to report the pooled prevalence along with 95% confidence interval. Discussion The results of this review study will provide valuable insights for clinicians, and policy makers, enabling them to formulate guidelines that underscore the importance of screening for BRCA mutations in cases of BOC.
AB - Purpose We present a methodically devised protocol for conducting a systematic review and metaanalysis aimed at ascertaining the prevalence of BReast CAncer gene (BRCA) mutations in breast and ovarian cancer (BOC) among women in India. The review will include cross-sectional, cohort, case-series, and registry-based studies focusing on females clinically diagnosed with any stage of BOC, tested for BRCA germline mutation and undergone any form of treatment. Methods A Cochrane literature search will be carried out to identify all the published and unpublished articles available in English from 2010 till date across various electronic databases including PubMed, Psych Info, SCI, Cochrane Central, Embase, Scopus, IND Med and Google Scholar. A step-by-step process will be followed to select all the relevant studies for final inclusion using Rayyan software. The selection process of the review will be reported based on Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA) checklist. The protocol has been registered in PROSPERO (ID: CRD42023463452). Joanna Briggs Institute Critical Appraisal Checklist will be used to evaluate the methodological quality of the included studies. The outcome measure will be the prevalence of BRCA1/2 gene mutation in this population. Meta-analysis will be performed to report the pooled prevalence along with 95% confidence interval. Discussion The results of this review study will provide valuable insights for clinicians, and policy makers, enabling them to formulate guidelines that underscore the importance of screening for BRCA mutations in cases of BOC.
KW - BRCA1 Protein
KW - BRCA2 Protein
KW - Breast Neoplasms
KW - Female
KW - Germ-Line Mutation
KW - Humans
KW - India
KW - Meta-Analysis as Topic
KW - Mutation
KW - Ovarian Neoplasms
KW - Prevalence
KW - Systematic Reviews as Topic
UR - http://www.scopus.com/inward/record.url?scp=85198708136&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0306612
DO - 10.1371/journal.pone.0306612
M3 - Article
C2 - 39012888
SN - 1932-6203
VL - 19
JO - PLoS One
JF - PLoS One
IS - 7
M1 - e0306612
ER -
