TY - JOUR
T1 - Prognostic value of variables derived from the six-minute walk test in patients with COPD
T2 - Results from the ECLIPSE study
AU - Andrianopoulos, Vasileios
AU - Wouters, Emiel F.M.
AU - Pinto-Plata, Victor M.
AU - Vanfleteren, Lowie E.G.W.
AU - Bakke, Per S.
AU - Franssen, Frits M.E.
AU - Agusti, Alvar
AU - MacNee, William
AU - Rennard, Stephen I.
AU - Tal-Singer, Ruth
AU - Vogiatzis, Ioannis
AU - Vestbo, Jørgen
AU - Celli, Bartolome R.
AU - Spruit, Martijn A.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - In addition to the six-min walk distance (6 MWD), other six-min walk test (6 MWT) derived variables, such as mean walk-speed (6MWSpeed), 6-min walk-work (6 MWW), distance-saturation product (DSP), exercise-induced oxygen desaturation (EID), and unintended stops may be useful for the prediction of mortality and hospitalization in patients with chronic obstructive pulmonary disease (COPD). We studied the association between 6 MWT-derived variables and mortality as well as hospitalization in COPD patients and compared it with the BODE index. A three-year prospective study (ECLIPSE) to evaluate the prognostic value of 6 MWT-derived variables in 2010 COPD patients. Cox's proportional-hazard regressions were performed to estimate 3-year mortality and hospitalization. During the follow-up, 193 subjects died and 622 were hospitalized. An adjusted Cox's regression model of hazard ratio [HR] for impaired 6 MWT-derived variables was significant referring to: mortality (6 MWD ≤334 m [2.30], 6MWSpeed ≤0.9 m/sec [2.15], 6 MWW ≤20000 m kg [2.17], DSP ≤290 m% [2.70], EID ≤88% [1.75], unintended stops [1.99]; and hospitalization (6 MWW ≤27000 m kg [1.23], EID ≤88% [1.25], BODE index ≥3 points [1.40]; all p ≤ 0.05). The 6 MWT-derived variables have an additional predictive value of mortality in patients with COPD. The 6 MWW, EID and the BODE index refine the prognosis of hospitalization.
AB - In addition to the six-min walk distance (6 MWD), other six-min walk test (6 MWT) derived variables, such as mean walk-speed (6MWSpeed), 6-min walk-work (6 MWW), distance-saturation product (DSP), exercise-induced oxygen desaturation (EID), and unintended stops may be useful for the prediction of mortality and hospitalization in patients with chronic obstructive pulmonary disease (COPD). We studied the association between 6 MWT-derived variables and mortality as well as hospitalization in COPD patients and compared it with the BODE index. A three-year prospective study (ECLIPSE) to evaluate the prognostic value of 6 MWT-derived variables in 2010 COPD patients. Cox's proportional-hazard regressions were performed to estimate 3-year mortality and hospitalization. During the follow-up, 193 subjects died and 622 were hospitalized. An adjusted Cox's regression model of hazard ratio [HR] for impaired 6 MWT-derived variables was significant referring to: mortality (6 MWD ≤334 m [2.30], 6MWSpeed ≤0.9 m/sec [2.15], 6 MWW ≤20000 m kg [2.17], DSP ≤290 m% [2.70], EID ≤88% [1.75], unintended stops [1.99]; and hospitalization (6 MWW ≤27000 m kg [1.23], EID ≤88% [1.25], BODE index ≥3 points [1.40]; all p ≤ 0.05). The 6 MWT-derived variables have an additional predictive value of mortality in patients with COPD. The 6 MWW, EID and the BODE index refine the prognosis of hospitalization.
KW - COPD
KW - Exercise physiology
KW - Exercise testing
KW - Hospitalization
KW - Mortality
KW - Prognostic markers
U2 - 10.1016/j.rmed.2015.06.013
DO - 10.1016/j.rmed.2015.06.013
M3 - Article
C2 - 26143282
AN - SCOPUS:84941737223
SN - 0954-6111
VL - 109
SP - 1138
EP - 1146
JO - Respiratory Medicine
JF - Respiratory Medicine
IS - 9
ER -