Proximicins A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete verrucosispora

Hans-Peter Fiedler; Christina Bruntner; Julia Riedlinger; Alan Bull; Gjert Knutsen; Michael Goodfellow; Amanda Jones; Luis Maldonado; Wasu Pathom-Aree; Winfried Beil; Kathrin Schneider; Simone Keller; Roderich Süssmuth

doi:10.1038/ja.2008.125

Proximicins A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete verrucosispora

Hans-Peter Fiedler, Christina Bruntner, Julia Riedlinger, Alan Bull, Gjert Knutsen, Michael Goodfellow, Amanda Jones, Luis Maldonado, Wasu Pathom-Aree, Winfried Beil, Kathrin Schneider, Simone Keller, Roderich Süssmuth

Applied Sciences Department

Research output: Contribution to journal › Article › peer-review

144 Citations (Scopus)

Abstract

A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown -amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.

Original language	English
Pages (from-to)	158-163
Journal	Journal of Antibiotics
Volume	61
DOIs	https://doi.org/10.1038/ja.2008.125
Publication status	Published - Mar 2008

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10.1038/ja.2008.125

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Fiedler, H-P., Bruntner, C., Riedlinger, J., Bull, A., Knutsen, G., Goodfellow, M., Jones, A., Maldonado, L., Pathom-Aree, W., Beil, W., Schneider, K., Keller, S., & Süssmuth, R. (2008). Proximicins A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete verrucosispora. Journal of Antibiotics, 61, 158-163. https://doi.org/10.1038/ja.2008.125

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abstract = "A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer {"}Verrucosispora maris{"} AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown -amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.",

author = "Hans-Peter Fiedler and Christina Bruntner and Julia Riedlinger and Alan Bull and Gjert Knutsen and Michael Goodfellow and Amanda Jones and Luis Maldonado and Wasu Pathom-Aree and Winfried Beil and Kathrin Schneider and Simone Keller and Roderich S{\"u}ssmuth",

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doi = "10.1038/ja.2008.125",

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Fiedler, H-P, Bruntner, C, Riedlinger, J, Bull, A, Knutsen, G, Goodfellow, M, Jones, A, Maldonado, L, Pathom-Aree, W, Beil, W, Schneider, K, Keller, S & Süssmuth, R 2008, 'Proximicins A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete verrucosispora', Journal of Antibiotics, vol. 61, pp. 158-163. https://doi.org/10.1038/ja.2008.125

TY - JOUR

T1 - Proximicins A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete verrucosispora

AU - Fiedler, Hans-Peter

AU - Bruntner, Christina

AU - Riedlinger, Julia

AU - Bull, Alan

AU - Knutsen, Gjert

AU - Goodfellow, Michael

AU - Jones, Amanda

AU - Maldonado, Luis

AU - Pathom-Aree, Wasu

AU - Beil, Winfried

AU - Schneider, Kathrin

AU - Keller, Simone

AU - Süssmuth, Roderich

PY - 2008/3

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N2 - A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown -amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.

AB - A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown -amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.

U2 - 10.1038/ja.2008.125

DO - 10.1038/ja.2008.125

M3 - Article

SN - 0021-8820

VL - 61

SP - 158

EP - 163

JO - Journal of Antibiotics

JF - Journal of Antibiotics

ER -

Proximicins A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete verrucosispora

Abstract

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