Proximicins A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete verrucosispora

Hans-Peter Fiedler, Christina Bruntner, Julia Riedlinger, Alan Bull, Gjert Knutsen, Michael Goodfellow, Amanda Jones, Luis Maldonado, Wasu Pathom-Aree, Winfried Beil, Kathrin Schneider, Simone Keller, Roderich Süssmuth

Research output: Contribution to journalArticlepeer-review

113 Citations (Scopus)

Abstract

A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown -amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.
Original languageEnglish
Pages (from-to)158-163
JournalJournal of Antibiotics
Volume61
DOIs
Publication statusPublished - Mar 2008

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