Pulse mode operation of Love wave devices for biosensing applications

Michael Newton; Glen McHale; Fabrice Martin; Electra Gizeli; Kathryn Melzak

doi:10.1039/b109259f

Pulse mode operation of Love wave devices for biosensing applications

Michael Newton, Glen McHale, Fabrice Martin, Electra Gizeli, Kathryn Melzak

EE Faculty Management and Administration

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

In this work we present a novel pulse mode Love wave biosensor that monitors both changes in amplitude and phase. A series of concentrations of 3350 molecular weight poly(ethylene glycol) (PEG) solutions are used as a calibration sequence for the pulse mode system using a network analyzer and high frequency oscilloscope. The operation of the pulse mode system is then compared to the continuous wave network analyzer by showing a sequence of deposition and removal of a model mass layer of palmitoyl-oleoyl-sn-glycerophosphocholine (POPC) vesicles. This experimental apparatus has the potential for making many hundreds of measurements a minute and so allowing the dynamics of fast interactions to be observed.

Original language	English
Pages (from-to)	2107-2109
Number of pages	3
Journal	Analyst
Volume	126
Issue number	12
DOIs	https://doi.org/10.1039/b109259f https://doi.org/10.1039/b109259f
Publication status	Published - 16 Nov 2001

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author = "Michael Newton and Glen McHale and Fabrice Martin and Electra Gizeli and Kathryn Melzak",

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AU - Newton, Michael

AU - McHale, Glen

AU - Martin, Fabrice

AU - Gizeli, Electra

AU - Melzak, Kathryn

PY - 2001/11/16

Y1 - 2001/11/16

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AB - In this work we present a novel pulse mode Love wave biosensor that monitors both changes in amplitude and phase. A series of concentrations of 3350 molecular weight poly(ethylene glycol) (PEG) solutions are used as a calibration sequence for the pulse mode system using a network analyzer and high frequency oscilloscope. The operation of the pulse mode system is then compared to the continuous wave network analyzer by showing a sequence of deposition and removal of a model mass layer of palmitoyl-oleoyl-sn-glycerophosphocholine (POPC) vesicles. This experimental apparatus has the potential for making many hundreds of measurements a minute and so allowing the dynamics of fast interactions to be observed.

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JO - Analyst

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Pulse mode operation of Love wave devices for biosensing applications

Abstract

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