Rapamycin in aging and disease: maximizing efficacy while minimizing side effects

Simon C Johnson, Matt Kaeberlein

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Experimental geroscience has identified rapamycin as a top candidate for promoting healthy aging and longevity in mammals. As multiple independent studies have successfully reproduced the lifespan and healthspan promoting effects of rapamycin, the focus has shifted to possible translational use. While a promising compound, clinical use of rapamycin is limited by concerns of side effects associated with the drug. Studies aimed at defining optimal dosage regimen, delivery route, and formulation will allow for benefits to be maximized while reducing side effects.

Original languageEnglish
Pages (from-to)44876-44878
Number of pages3
JournalOncotarget
Volume7
Issue number29
DOIs
Publication statusPublished - 19 Jul 2016
Externally publishedYes

Fingerprint

Dive into the research topics of 'Rapamycin in aging and disease: maximizing efficacy while minimizing side effects'. Together they form a unique fingerprint.

Cite this